Chromosomal aberrations and micronucleus frequency in nurses occupationally exposed to cytotoxic drugs |
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| Authors: | Anwar, Wagida A. Salama, Somaia I. Serafy, Mostafa M.EI Hemida, Samia A. Hafez, Ahmed S. |
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| Affiliation: | 1Department of Community, Environmental and Occupational Medicine, Faculty of Medicine, Ain Shams University Cairo 2Community Research Department, National Research Center Cairo 3Intenal Medicine and Medical Oncology Department National Cancer Institute Cairo, Egypt |
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| Abstract: | In this study, we evaluated the effect of low level occupationalexposure of nurses in a medical oncology unit in Cairo, Egypt,to anticancer drugs. Twenty nurses who constantly handled thesedrugs and 20 controls, matched according to age and sex, wereexamined. Metaphase chromosomes were studied. Percentages ofmetaphases with chromosomal aberrations were significantly higher(P < 0.001) in the exposed group (6.1 ± 2.7) versusthe controls (2.6 ± 1.6). The detected chromosomal aberrationswere in the form of chromatid gaps, chromatid breaks and acentricfragments. Micronucleated peripheral blood lymphocytes werealso analyzed in cytochalasin B treated binucleated lymphocytes.There was significant increase in cells with micronuclei (P< 0.001) in nurses (10.05 ± 4.71) in comparison tothe matched control (5.42 ± 2.22) (P < 0.001). Nursesexposed to the cytotoxic drugs for |
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