| 新疆准噶尔乌头高效液相色谱指纹图谱的建立 |
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| 引用本文： | 赵翡翠,闫向君,王伟,吴桂荣,聂继红. 新疆准噶尔乌头高效液相色谱指纹图谱的建立[J]. 中国医院药学杂志, 2015, 35(6): 485-490. DOI: 10.13286/j.cnki.chinhosppharmacyj.2015.06.04 |
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| 作者姓名： | 赵翡翠 闫向君 王伟 吴桂荣 聂继红 |
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| 作者单位： | 1. 新疆医科大学, 新疆 乌鲁木齐 830011;2. 新疆医科大学附属中医医院, 新疆 乌鲁木齐 830000;3. 新疆吉木萨尔县中医医院, 831700;4. 聊城市人民医院, 山东 聊城 252002 |
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| 基金项目： | 新疆维吾尔自治区卫生厅青年科技人才专项科研项目(编号:2013Y03);新疆名医名方与特色方剂学实验室开放基金(编号:XJDX0910-2013-10) |
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| 摘 要： | 目的:建立准噶尔乌头HPLC指纹图谱,为新疆准噶尔乌头质量控制提供方法学依据.方法:以正交试验方法多指标优化准噶尔乌头HPLC指纹图谱供试品前处理方法,建立准噶尔乌头HPLC指纹图谱,并对其主要色谱峰进行归属性鉴别.结果:建立的指纹图谱分离度好,稳定性高,得到准噶尔乌头4个特征峰,分别是苯甲酰乌头原碱、苯甲酰次乌头原碱、乌头碱和未命名化合物1.结论:建立的准噶尔乌头HPLC指纹图谱供试品前处理方法和色谱条件可行、全面,为新疆准噶尔乌头质量控制奠定基础.
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| 关 键 词： | 准噶尔乌头 高效液相色谱指纹图谱 正交设计 质量控制 |
| 收稿时间： | 2014-07-09 |
Construction of HPLC fingerprints for Aconitum soongaricum Stapf. from Xinjiang |
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| ZHAO Fei-cui;YAN Xiang-jun;WANG Wei;WU Gui-rong;NIE Ji-hong. Construction of HPLC fingerprints for Aconitum soongaricum Stapf. from Xinjiang[J]. Chinese Journal of Hospital Pharmacy, 2015, 35(6): 485-490. DOI: 10.13286/j.cnki.chinhosppharmacyj.2015.06.04 |
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| Authors: | ZHAO Fei-cui YAN Xiang-jun WANG Wei WU Gui-rong NIE Ji-hong |
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| Affiliation: | 1. Xinjiang Medical University, Xinjiang Urumqi 830011, China;2. Affiliated TCM Hospital to Xinjiang Medical University, Xinjiang Urumqi 830000, China;3. Xinjiang Jimsar County TCM Hospital, Xinjiang Jimsar 831700, China;4. Liaocheng People's Hospital, Shandong Liaocheng 252002, China |
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| Abstract: | OBJECTIVE To establish HPLC fingerprints for Aconitum soongaricum Stapf.,provide methological basis for quality control of Aconitum soongaricum Stapf.from Junggar,Xinjiang. METHODS Multi-index orthogonal design method was used to screen aconitum HPLC fingerprints and optimize chromatographic conditions,and establish HPLC fingerprint spectra of Aconitum soongaricum Stapf. RESULTS The established fingerprints had good separating degree and high stability,including four characteristic peaks, which respectively was benzoylaconine,benzoylhypacoitine,aconitine and unnamed compound 1.CONCLUSION The extraction process and chromatographic conditions for Aconitum soongaricum Stapf.are feasible,comprehensive,and the HPLC chromatographic fingerprints lays a certain methodological foundation for researches on Aconitum plants in Xinjiang. |
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| Keywords: | Aconitum soongaricum Stapf HPLC fingerprints orthogonal design quality control |
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