| 调脂药物对动物与临床试验疗效的比较 |
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| 引用本文： | 樊希承,黄颖,黄亦琦,杨辉,罗友华,王梅兰. 调脂药物对动物与临床试验疗效的比较[J]. 实用医技杂志, 2011, 18(8): 791-792 |
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| 作者姓名： | 樊希承 黄颖 黄亦琦 杨辉 罗友华 王梅兰 |
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| 作者单位： | 福建省厦门市医药研究所,361003 |
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| 基金项目： | 福建省厦门市科技局资助项目 |
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| 摘 要： | 目的对调脂药物动物实验和临床试验治疗结果进行对比和评价。方法动物实验建立高脂血症大鼠模型,将大鼠分为对照组、模型组（造模成功后,分为药物治疗组和自然恢复组）,测各组血液生化指标并作比较。临床试验：选取高脂血症患者,排除糖尿病及其他心血管系统疾病等。服药前后测定多种血清生化指标与健康对照组进行比较。结果调脂药物对动物实验和临床试验均有很明显降血脂作用。临床试验结果显示差异有统计学意义（P〈0.05）,动物实验结果显示差异有统计学意义（P〈0.01）。结论调脂药物对高脂血症大鼠模型和高脂血症患者均有临床疗效。
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| 关 键 词： | 降血脂药 动物实验 临床试验 对比研究 |
The efficacy of lipid lowering drugs on animals and clinical trials |
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| FAN Xi-cheng,HUANG Ying,HUANG Yi-qi,YANG Hui,LUO You-hua,WANG Mei-lan. The efficacy of lipid lowering drugs on animals and clinical trials[J]. Journal of Practical Medical Techniques, 2011, 18(8): 791-792 |
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| Authors: | FAN Xi-cheng HUANG Ying HUANG Yi-qi YANG Hui LUO You-hua WANG Mei-lan |
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| Affiliation: | FAN Xi-cheng,HUANG Ying,HUANG Yi-qi,YANG Hui,LUO You-hua,WANG Mei-lan.Xiamen Medicine Research Institute,Fujian 361003,China |
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| Abstract: | Objective To compare and evaluate efficacy of the animal experiments and clinical trials of drug treatment.Methods Animal experiments: The high cholesterol rats model was established.All the rats were divided into 2 groups: control group and model group which was divided into treatment group and natural recovery group after modeling success.The blood biochemical parameters of each group were detected and compared.Clinical trials: the patients with high cholesterol and without diabetes and other cardiovascul... |
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| Keywords: | Antilipemic agents Animal experimentation Clinical trial Comparative study |
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