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Pancreatic endocrine and exocrine changes in celiac disease
Authors:Freeman Hugh J
Affiliation:Department of Medicine Gastroenterology, University of British Columbia, Vancouver, BC, Canada
Abstract:
Although there is a great deal of information on celiac disease and associated involvement of other non-intestinal sites,data on concomitant changes in the structure and function of the pancreas is limited. The present review critically examines pancreatic endocrine changes that have been well documented in the literature,including insulin-dependent diabetes mellitus. Pancreatic exocrine alterations may also occur,and if severe,marked malnutrition with pancreatic failure and ductal calcification have been observed. Finally,other pancreatic disorders have been recorded with celiac disease.
Keywords:Celiac disease  Gluten-sensitive enteropathy  Diabetes mellitus  Chronic pancreatitis  Pancreatic function
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