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| 蛋白质组学在中药方剂药理研究中的应用进展 | |
| 引用本文： | 刘玉倩,詹淑玉,阮钰尔,左志燕,季晓明,王帅杰,丁宝月. 蛋白质组学在中药方剂药理研究中的应用进展[J]. 中国中药杂志, 2017, 42(20): 3873-3879 |
| 作者姓名： | 刘玉倩 詹淑玉 阮钰尔 左志燕 季晓明 王帅杰 丁宝月 |
| 作者单位： | 嘉兴学院 医学院, 浙江 嘉兴 314001,嘉兴学院 医学院, 浙江 嘉兴 314001,嘉兴学院 医学院, 浙江 嘉兴 314001,嘉兴学院 医学院, 浙江 嘉兴 314001,嘉兴学院 医学院, 浙江 嘉兴 314001,嘉兴学院 医学院, 浙江 嘉兴 314001,嘉兴学院 医学院, 浙江 嘉兴 314001 |
| 基金项目： | 国家自然科学基金项目（81503338）；浙江省公益性技术应用研究计划项目（2017C37137）；浙江省嘉兴市科技计划项目（2015AY23064）；国家级大学生创新创业训练计划项目（201710354009）；浙江省大学生科技创新活动计划（新苗人才计划）项目（2016R417039）；嘉兴学院重点SRT项目（SRT2016B030） |
| 摘 要： | 中药方剂是中药临床治病的重要手段,其多组分、多靶点、整合调节的作用特点迫切需要运用现代先进的科学技术手段来揭示其复杂的作用机制。蛋白质组学系统性、全方位的研究模式正好与中药方剂的作用特点相契合,已经逐渐广泛应用于中药方剂的药理作用机制研究中。该文对近年来蛋白质组学在中药方剂抗心脑血管疾病、抗肝脏疾病、抗糖尿病、抗癌、抗类风湿性关节炎以及其他疾病的药理研究中的应用进行了综述,并提出未来发展的方向,以期为中药方剂作用机制的蛋白质组学研究提供思路和方法参考。 |
| 关 键 词： | 蛋白质组学 中药方剂 药理研究 |
| 收稿时间： | 2017-06-05 |
Application progress of proteomic in pharmacological study of Chinese medicinal formulae |
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| LIU Yu-qian,ZHAN Shu-yu,RUAN Yu-er,ZUO Zhi-yan,JI Xiao-ming,WANG Shuai-jie and DING Bao-yue. Application progress of proteomic in pharmacological study of Chinese medicinal formulae[J]. China Journal of Chinese Materia Medica, 2017, 42(20): 3873-3879 | |
| Authors: | LIU Yu-qian ZHAN Shu-yu RUAN Yu-er ZUO Zhi-yan JI Xiao-ming WANG Shuai-jie DING Bao-yue |
| Affiliation: | Medical College, Jiaxing University, Jiaxing 314001, China,Medical College, Jiaxing University, Jiaxing 314001, China,Medical College, Jiaxing University, Jiaxing 314001, China,Medical College, Jiaxing University, Jiaxing 314001, China,Medical College, Jiaxing University, Jiaxing 314001, China,Medical College, Jiaxing University, Jiaxing 314001, China and Medical College, Jiaxing University, Jiaxing 314001, China |
| Abstract: | Chinese medicinal formulae are the important means of clinical treatment in traditional Chinese medicine. It is urgent to use modern advanced scientific and technological means to reveal the complicated mechanism of Chinese medicinal formulae because they have the function characteristics of multiple components, multiple targets and integrated regulation. The systematic and comprehensive research model of proteomic is in line with the function characteristics of Chinese medicinal formulae, and proteomic has been widely used in the study of pharmacological mechanism of Chinese medicinal formulae. The recent applications of proteomic in pharmacological study of Chinese medicinal formulae in anti-cardiovascular and cerebrovascular diseases, anti-liver disease, antidiabetic, anticancer, anti-rheumatoid arthritis and other diseases were reviewed in this paper, and then the future development direction of proteomic in pharmacological study of Chinese medicinal formulae was put forward. This review is to provide the ideas and method for proteomic research on function mechanism of Chinese medicinal formulae. |
| Keywords: | proteomic Chinese medicinal formulae pharmacological study |
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