阿司匹林联合氯吡格雷治疗不稳定型心绞痛的疗效观察

目的探讨氯吡格雷与阿司匹林联合应用治疗不稳定型心绞痛（UAP）的临床疗效和安全性。方法 187例UAP患者随机分成治疗组（96例）和对照组（91例）,均常规应用抗心绞痛药物治疗。治疗组在常规治疗的同时,首次给负荷剂量的氯吡格雷300mg口服,继之75mg口服。治疗期间记录两组心绞痛的发作情况、12导联心电图变化及药物主要不良反应等。结果 UAP患者中、高危险组,与单用阿司匹林相比,联合氯吡格雷使临床症状改善的总有效率分别提高26.2%和25.1%;治疗组心血管事件的发生率比对照组下降11.5%,均未见严重不良反应。结论氯吡格雷与阿司匹林联合应用治疗UAP疗效满意,优于单独应用阿司匹林的常规治疗效果。

Effective Observation on the Combination of Aspirin and Clopidogrel in the Treatment of Unstable Angina

Objective To investigate the effect and safety of the combined therapy of clopidogrel and aspirin in patients with unstable angina pectoris（UAP）.Methods 187 patients with UAP,who was undergoing standard treatment（aspirin,low molecular heparin,nitrate and β-receptor blocker）,were randomly divided into test group（n=96） and control group（n=91）.The test group was administered a course of additional clopidogrel（loading dose 300mg,daily dose 75mg）.The results were compared four weeks later.Results Evaluation of symptomatic relief and improvement of ST depression on ECG justified that the rate of effectiveness was 86.8% and 65.3% for the test group and the control group respectively,and the difference was significant（P〈0.05）.No severe adverse efects were found in either group.Conclusion The treatment with combined clopidogrel and aspirin is superior to the conventional therapy containing aspirin alone for unstable angina.