慢性心力衰竭的细胞信号转导机制

慢性心力衰竭（chronicheartfailure,CHF）是指各种原因引起心脏泵功能受损,致使心输出量减少,不能满足机体组织代谢需要,并出现心室充盈压升高、体（肺）循环淤血的临床综合征。近年来随着人口老龄化的出现,以及冠心病急性心肌梗塞死亡率的下降,CHF的发病率呈上升趋势,在美国每年有50万人发生心力衰竭’‘’。CHF严重影响老年人生活质量,是发达国家患病率和死亡率最高的疾病之一。CHF发生与发展过程中,多种基因、生理和环境因素共同作用,造成与心肌收缩蛋白功能和兴奋．收缩耦联相关的分子发生变化,如肌球蛋白头部CaZ”－…

Cellular signal transduction in chronic heart failure

Chronic heart failure(CHF ) occurs when abnormality of cardiac function causes the heart to fail to pump bloodat a rate required by the metabolising tissue. CHF is highly complex disorders that arise as a result of combination of genetic,pathophysiologic, and environmental factors. Cellular transduction plays an important role in the pathogenesis of CHF andmany signaling molecules, rebeptors, and intracellular signaling paths are involved. Peptide hormones, growth factors, andcytokines can activate heteromeric (Gq ) or low-molecular-weight guanosine triphosphate (GTP) -binding protein (ras ), andthe transmembrane signal transducer gp130 and induce CHF respectively. Recently it is reported that calcineurin (a Ca2 /calmodulin dependent phosphoprotein phosphatase) plays a significant role in myocyte hypertrophy and heart failure. Thepresent article reviews the progress in cellular signal transduction mechanisms in CHF.