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| 大肠癌bcl-2、nm23基因蛋白的表达与临床随访研究 | |
| 引用本文： | 高冰 张志强 路树强. 大肠癌bcl-2、nm23基因蛋白的表达与临床随访研究[J]. 中华综合临床医学杂志(山东), 2005, 7(11): 901-902 |
| 作者姓名： | 高冰 张志强 路树强 |
| 作者单位： | 北京航空工业中心医院,北京100012 |
| 摘 要： | 目的研究检测bcl-2、nm23基因在大肠癌的诊断和判断患者顸后中的作用。方法应用免疫组化和流式细胞术的方法对60例大肠癌标本进行定性及定量的检测，并追踪回访患者的预后10年。结果bcl-2基因的定性表达阳性率及定量检测值较正常粘膜相比有显著差异，但其表达阳性率与患者的预后并没有明显的相关性；nm23基因定性表达阳性率及定量检测值与正常粘膜相比差异不显著，但其表达与患者预后有显著差异性。结论进行以上两种基因的免疫组化检测对临床诊断及判断顸后有参考价值。 |
| 关 键 词： | 大肠癌 基因蛋白 |
| 文章编号： | 1728-7324-（2005）011-0901-02 |
Expression and significance of oncoprotein bcl-2 , nm23 in colorectal carcinoma. |
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| Gao bing ,Zhang zhiqiang ,Lu shuqiang.. Expression and significance of oncoprotein bcl-2 , nm23 in colorectal carcinoma.[J]. , 2005, 7(11): 901-902 | |
| Authors: | Gao bing Zhang zhiqiang Lu shuqiang. |
| Affiliation: | Central Hospital of Aviation Industry Beijing |
| Abstract: | Objective To study the Expression and significance of bcl-2 , nm23 in colorectal carcinoma. Methods 60 cases with colorectal carcinoma had been examined the Quality and ration expression of the oncoproteins and had been reviewed researching for 10 years. Results It is significant that the differentce of positive rate of bcl-2 between carcinoma and normal mucosa , but it isn, t significant of nm23. Examining nm23 oncoprotein is importantly for prognosis of sufferers. Conclusion Examining bcl-2, nm23 oncoprotein is a simple and convenient method in hospital. |
| Keywords: | colorectal carcinoma oncoprotein |
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