Compartmental analysis of the effect of carbon tetrachloride intoxication on blood and bile kinetics of sulfobromophthalein in rats

In rats intoxicated by CCl₄ (2.5 ml/kg by stomach tube or 10 ml/kg i.m.), the plasma and bile BSP kinetics were fitted to a four-compartment model. The effect of CCl₄ was analyzed by the changes brought about in the five transfer constants which characterize the model. Intrahepatic BSP transfer and liver uptake are the parameters most sensitive to CCl₄ intoxication. The peak effect is obtained 1 day after the intoxication, with a rapid return to normality.Part of the present work has been performed under a grant from the Consiglio Nazionale delle Ricerche (Grant No. 71.0024.09).