Anti-hepatitis A virus immunoglobulin M antibodies in urine samples for rapid diagnosis of outbreaks |
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| Authors: | Rodríguez Lay Licel de los Angeles Larralde Díaz Osmany Martínez Casanueva Raiza Gutiérrez Moreno Aidonis |
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| Affiliation: | Institute for Tropical Medicine Pedro Kourí, Department of Virology, National Reference Laboratory of Viral Hepatitis, Havana City, Cuba. licel@ipk.sld.cu |
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| Abstract: | ![]()
The main goal of this study was to test the feasibility of using urine for diagnosing hepatitis A virus (HAV) infections. A correlation of 90.78% between the test results of urine and serum samples was obtained. Four outbreaks of hepatitis A were confirmed by testing only urine samples. The levels of anti-HAV immunoglobulin M (IgM) antibodies in urine samples remained stable during 6 months of storage at -70 degrees C but decreased when the samples were stored at 4 degrees C. The results of tests of samples obtained 2 and 6 months after infection suggested that IgM levels decline more rapidly in urine than in serum. |
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