| 非小细胞肺癌患者血清CYFRA21-1浓度与病理分期关系的探讨 |
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| 引用本文： | 尚文军,周耀洪,王晓丽,吴亦志,李军. 非小细胞肺癌患者血清CYFRA21-1浓度与病理分期关系的探讨[J]. 放射免疫学杂志, 2010, 23(4): 368-369 |
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| 作者姓名： | 尚文军 周耀洪 王晓丽 吴亦志 李军 |
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| 作者单位： | 浙江省丽水市人民医院,323000;山东大学附属省立医院,250021;江西省肿瘤医院,330029 |
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| 基金项目： | 山东省自然科学基金,山东省博士后创新基金,江西省自然基金 |
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| 摘 要： | 目的：研究非小细胞肺癌患者血清CYFRA21-1浓度与病理分期的关系。方法：应用放射免疫分析224例非小细胞肺癌患者血清CYFRA21-1的浓度,统计分析其与术后病理T、N分期的关系。结果：非小细胞肺癌患者血清CYFRA21-1浓度与T分期（T1vsT2,T1vsT3,P〈0.05）及淋巴结转移（pN0vspN1,pN0vspN2,pN1vspN2,P〈0.05）有显著统计学差异。结论：术前检测非小细胞肺癌患者血清CYFRA21-1浓度对判断T、N分期有重要的临床意义。
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| 关 键 词： | 非小细胞肺癌 肿瘤标志物 细胞角蛋白19片段 |
Study on the Relationship Between Serum Concentration of CYFRA21-1 and Pathological Staging in Patients with Non-Small Cell Lung Cancer |
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| Affiliation: | Shang Wen-jun,Zhou Yao-hong,Wang Xiao-li,et al.(Lishui People＇s Hospital,Lishui(323000),China2Provincial Hospital Affiliated to Shandong University,Jinan,Shandong(250021),China ) |
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| Abstract: | Objective To study the relationship between of serum concentrations of CYFRA21-1 and to pathological staging in patients with non-small cell lung cancer.Methods Serum concentrations of CYFRA21-1 were determined with IRMA in 224 patients with non-small cell lung cancer.Results The serum CYFRA21-1 levels in patients with non-small cell lung carcinoma increased gradually as the tumor size enlarged.Levels in patients of T2 and T3 stages were significantly higher than those in patients of T1 stage,but the difference between those in patients of T2 stage and T3 stage were not significant.The serum CYFRA21-1 levels also incroased as the number of lymph nodes with metastasis increased.Differences of serum levels of CYFRA21-1 in patients of consecutive lymph node stages were all significant.Conclusion Preoperative detection of the serum concentration of CYFRA21-1 in patient with non-small cell lung cancer has important clinical significance on the judgement of T,N stages. |
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| Keywords: | non-small-cell lung cancer tumor marker CYFRA21-1 |
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