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| APE1/Ref-1在胃癌组织中的表达及意义 | |
| 引用本文： | 郭云娣,陈建华. APE1/Ref-1在胃癌组织中的表达及意义[J]. 江苏医药, 2011, 37(14) |
| 作者姓名： | 郭云娣 陈建华 |
| 作者单位： | 1. 苏州卫生职业技术学院苏州检验医学生物技术重点实验室,215009 2. 苏州市立医院普通外科 |
| 摘 要： | 目的探讨脱嘌呤脱嘧啶核酸内切酶/氧化还原因子(APE1/Ref-1)蛋白在胃癌组织中的表达及意义。方法利用组织芯片技术和免疫组化EnVision法检测APE1/Ref-1蛋白在99例胃癌组织中的表达。其中,无淋巴结转移者27例,有淋巴结转移者72例。结果 APE1/Ref-1在胃癌中的阳性表达率为63.64%。其在无淋巴结转移者为37.01%,明显低于有淋巴结转移者的73.61%(P<0.05)。结论 APE1/Ref-1可能通过对增强胃癌组织DNA碱基损伤的修复而参与了胃癌的浸润及转移的机制。 |
| 关 键 词： | APE1/Ref-1蛋白 胃癌 |
Expression and significance of APE1/Ref-1 in gastric carcinoma |
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| GUO Yundi,CHEN Jianhua. Expression and significance of APE1/Ref-1 in gastric carcinoma[J]. Jiangsu Medical Journal, 2011, 37(14) | |
| Authors: | GUO Yundi CHEN Jianhua |
| Affiliation: | GUO Yundi,CHEN Jianhua.Key Laboratory of Biotechnology for Laboratory Medicine,Soochow Health College,Suzhou 215009,CHINA |
| Abstract: | Objective To investigate the expression and significance of APE1/Ref-1 protein in gastric carcinoma.Methods The expression of APE1/Ref-1 protein was detected by EnVision immunohistochemical method in tissues-microarry in 99 cases of gastric carcinoma with lymphatic metastasis(grop A,72 cases) and without(group B,27 cases).Results The positive expression rate of APE1/Ref-1 in gastric carcinoma tissues was 63.64%,which was higher in group A than that in group B(73.61% vs.37.01%)(P<0.05).Conclusion APE1/Ref-1 ... |
| Keywords: | APE1/Ref-1 protein Gastric carcinoma |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |