Mitochondrial dysfunction and Alzheimer's disease |
| |
| Authors: | Aleksandra Maruszak Cezary ?ekanowski |
| |
| Affiliation: | Department of Neurodegenerative Disorders, Mossakowski Medical Research Centre, Polish Academy of Sciences, Pawińskiego 5 Str., 02-106 Warszawa, Poland |
| |
| Abstract: | To date, one of the most discussed hypotheses for Alzheimer's disease (AD) etiology implicates mitochondrial dysfunction and oxidative stress as one of the primary events in the course of AD. In this review we focus on the role of mitochondria and mitochondrial DNA (mtDNA) variation in AD and discuss the rationale for the involvement of mitochondrial abnormalities in AD pathology. We summarize the current data regarding the proteins involved in mitochondrial function and pathology observed in AD, and discuss the role of somatic mutations and mitochondrial haplogroups in AD development. |
| |
| Keywords: | ABAD, amyloid-beta (Aβ) binding alcohol dehydrogenase AD, Alzheimer's disease APOE2, Apolipoprotein E epsilon-2 allele APOE3, Apolipoprotein E epsilon-3 allele APOE4, Apolipoprotein E epsilon-4 allele APP, amyloid precursor protein ATP, Adenosine-5'-triphosphate Aβ, amyloid beta CMRglc, cerebral metabolic rate for glucose COX, cytochrome c oxidase CR, control region CypD, cyclophilin D DLP1, dynamin-like protein 1 FDG, 2-[18F]fluoro-2-deoxy- smallcaps" >d-glucose ETC, electron transport chain KDHC, alpha ketoglutarate dehydrogenase complex LHON, Leber's hereditary optic neuropathy MCI, mild cognitive impairment mtDNA, mitochondrial DNA Mfn1, mitofusin 1 Mfn2, mitofusin 2 OPA1, optic atrophy 1 protein mPTP, mitochondrial permeability pore NFT, neurofibrillary tangles OXPHOS, oxidative phosphorylation PDHC, puryvate dehydrogenase complex PET, positron emission tomography PiB, Pittsburgh compound B PreP, presequence protease ROS, reactive oxygen species rRNA, ribosomal ribonucleic acid TCA, tricarboxylic acid TOM40, mitochondrial translocase of outer mitochondrial membrane 40 homolog tRNA, transfer ribonucleic acid |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
