Subcortical brain volumes relate to neurocognition in schizophrenia and bipolar disorder and healthy controls |
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| Authors: | Hartberg Cecilie B Sundet Kjetil Rimol Lars M Haukvik Unn K Lange Elisabeth H Nesvåg Ragnar Melle Ingrid Andreassen Ole A Agartz Ingrid |
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| Affiliation: | a Institute of Clinical Medicine, Psychiatry Section, University of Oslo, Norwayb Department of Psychology, University of Oslo, Norwayc Department of Psychiatry, Diakonhjemmet Hospital, Oslo, Norwayd Division of Mental Health and Addiction, Psychosis Research Unit, Oslo University Hospital, Norwaye Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway |
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| Abstract: | ![]()
BackgroundSimilar patterns of subcortical brain abnormalities and neurocognitive dysfunction have been demonstrated in schizophrenia and bipolar disorder, with more extensive findings in schizophrenia. It is unknown whether relationships between subcortical volumes and neurocognitive performance are similar or different between schizophrenia and bipolar disorder.MethodsMRI scans and neuropsychological test performance were obtained from 117 schizophrenia or 121 bipolar spectrum disorder patients and 192 healthy control subjects. Using the FreeSurfer software, volumes of 18 selected subcortical structures were automatically segmented and analyzed for relationships with results from 7 neurocognitive tests.ResultsIn schizophrenia, larger left ventricular volumes were related to poorer motor speed, and bilateral putamen volumes were related to poorer verbal learning, executive functioning and working memory performance. In bipolar disorder, larger left ventricular volumes were related to poorer motor speed and executive functioning. The relationship between left putamen volume and working memory was specific to schizophrenia. The relationships between left inferior lateral ventricles and motor speed and between right putamen volumes and executive functioning were similar in schizophrenia and bipolar disorder, and different from healthy controls. The results remained significant after corrections for use of antipsychotic medication. Significant structure-function relationships were also found when all subjects were combined into one group.ConclusionThe present findings suggest that there are differences as well as similarities in subcortical structure/function relationships between patients with schizophrenia or bipolar disorder and healthy individuals. The observed differences further suggest that ventricular and putamen volume sizes may reflect severity of cognitive dysfunction in these disorders. |
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| Keywords: | AP, Antipsychotic ANOVA, Analysis of variance ANCOVA, Analysis of covariance CVLT, California Verbal Learning test DDD, Defined Daily Doses DSM-IV, Diagnostic and Statistical Manual of Mental Disorders D-KEFS, Delis-Kaplan Executive Function System GAF, Global Assessment of Functioning ICV, Intracranial volume MRI, Magnetic resonance imaging PANSS, Positive and Negative Syndrome Scale PRIME-MD, Primary Care Evaluation of Mental Disorders SCID, Structured Clinical Interview for DSM-IV TOP, Thematically Organized Psychosis Study WAIS, Wechsler Adult Intelligence Scale WASI, Wechsler Abbreviated Scale of Intelligence |
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