Association study of PDE4B with panic disorder in the Japanese population |
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| Authors: | Otowa Takeshi Kawamura Yoshiya Sugaya Nagisa Yoshida Eiji Shimada Takafumi Liu Xiaoxi Tochigi Mamoru Umekage Tadashi Miyagawa Taku Nishida Nao Kaiya Hisanobu Okazaki Yuji Tokunaga Katsushi Sasaki Tsukasa |
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| Affiliation: | a Department of Neuropsychiatry, Graduate School of Medicine, the University of Tokyo, Tokyo 113-8655, Japanb Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298, USAc Faculty of Human Science, Waseda University, Saitama 359-1192, Japand Outpatient Clinic for Anxiety Disorders, Akasaka Mental Clinic, Tokyo 107-0052, Japane Department of Human Genetics, Graduate School of Medicine, the University of Tokyo, Tokyo 113-8655, Japanf Resarch Center for Panic Disorder, Nagoya Mental Clinic, Aichi 453-0015, Japang Department of Neurology, Tokyo Metropolitan Matsuzawa Hospital, Tokyo 156-0057, Japanh Office for Mental Health Support and Graduate School of Education, University of Tokyo, Tokyo 113-8625, Japan |
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| Abstract: | BackgroundPanic disorder (PD) is a severe and chronic psychiatric disorder with genetic components underlying in its etiology. The Phosphodiesterase 4B (PDE4B) gene has been reported to be associated with several psychiatric disorders. Several studies indicated that PDE4B may be involved in the regulation of anxiety and depression. Therefore, we investigate the association of PDE4B with PD in the Japanese population.MethodsWe genotyped 14 single nucleotide polymorphisms (SNPs) of PDE4B in 231 PD cases (85 males and 146 females) and 407 controls (162 males and 245 females). Differences in the genotype, allele and haplotype frequencies between the two groups were compared.ResultsWe found a significant association between PDE4B and PD in the haplotype analysis (haplotype C-T-T-A, permutation P = 0.031, OR = 1.81, 95% CI = 1.30-2.51). Sex-specific analyses demonstrated that PDE4B was associated with PD in females in the allele/genotype and haplotype analyses (rs10454453, allele P = 0.042, genotype P = 0.0034; haplotype C-T-T-A, permutation P = 0.028).ConclusionOur results suggest that PDE4B may play a role in the pathophysiology of PD in the Japanese population. Replication studies using larger samples will be needed for more reliable conclusions. |
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| Keywords: | PD, panic disorder cAMP, cyclic adenosine monophosphate PDE4B, phosphodiesterase 4B DISC1, Disrupted in Schizophrenia 1 SNP, single nucleotide polymorphism MINI, Mini-International Neuropsychiatric Interview SSRI, serotonin selective reuptake inhibitor CREB, cAMP response element binding protein LD, linkage disequilibrium TDT, transmission disequilibrium test SD, standard deviation OR, odds ratio CI, confidence interval |
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