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| 抗结缔组织生长因子小分子干扰RNA防治大鼠肝纤维化的研究 | |
| 引用本文： | 薛苗,毛小荣,陈红,岳伟. 抗结缔组织生长因子小分子干扰RNA防治大鼠肝纤维化的研究[J]. 肝脏, 2011, 16(1): 41-44 |
| 作者姓名： | 薛苗 毛小荣 陈红 岳伟 |
| 作者单位： | 兰州大学第一医院传染科.,730000 |
| 基金项目： | 甘肃省自然科学研究基金计划(2008GS01165) |
| 摘 要： | 目的 探讨经腹腔注射抗结缔组织生长因子(CTGF)小分子干扰RNA(siRNA)是否能抑制大鼠体内肝脏CTGF基因表达及防治大鼠肝纤维化.方法 雄性SD大鼠30只,随机分成5组,分别为模型组腹腔注射40%CCl4 (3 mL/kg)及尾静脉注射生理盐水,1次/3 d,连续8周;预防组腹腔注射40%CCl4 及尾静脉注射... |
| 关 键 词： | 结缔组织生长因子 小分子干扰RNA 肝纤维化 |
Small interfering RNA targeting connective tissue growth factor inhibits rat liver fibrosis in vivo |
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| XUE Miao,MAO Xiao-rong,CHEN Hong,YUE Wei. Small interfering RNA targeting connective tissue growth factor inhibits rat liver fibrosis in vivo[J]. Chinese Hepatology, 2011, 16(1): 41-44 | |
| Authors: | XUE Miao MAO Xiao-rong CHEN Hong YUE Wei |
| Affiliation: | XUE Miao,MAO Xiao-rong,CHEN Hong,YUE Wei Department of Infectious disease,The First Affiliated Hospital of Lanzhou University,Lan Zhou 730000,China |
| Abstract: | Objective To explore whether the intraperitoneal injection of small interfering RNA(siRNA) targeting connective tissue growth factor(CTGF) could inhibit CTGF expression in rats liver in vivo and prevent rats hepatic fibrosis.Methods Thirty male rats were randomly divided into five groups.Rats received intraperitoneally injection of 40% CCl 4(3 mL/ kg) together with tail vein injection of saline every three days for 8 consecutive weeks were served as model group;CCl4 together with tail vein delivery of siRNA... |
| Keywords: | Connective tissue growth factor Small interferon RNA Liver fibrosis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |