| 慢性HBV携带者YMDD自然变异的追踪研究 |
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| 引用本文： | 屈军校,曾庆磊,李春霞,冯继红,徐光华.慢性HBV携带者YMDD自然变异的追踪研究[J].肝脏,2011,16(1):17-19. |
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| 作者姓名： | 屈军校 曾庆磊 李春霞 冯继红 徐光华 |
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| 作者单位： | 陕西省延安大学附属医院感染病科,716000 |
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| 基金项目： | 延安市科技计划项目(2007) |
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| 摘 要： | 目的 探讨慢性HBV携带者YMDD自然变异随时间的推移发生变化的情况.方法 随机选择未经抗病毒治疗的慢性HBV携带者103例,分别在开始、1年、2年时观察血清HBV DNA、HBV血清学标志物、肝功能、YMDD变异的变化情况.结果 在开始检测的103例慢性HBV携带者中,YMDD阳性27例,观察2年后4例转为非活动性H...
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| 关 键 词： | 慢性HBV携带者 YMDD自然变异 追踪研究 |
Tracing study on spontaneous HBV YMDD mutation in chronic HBV carriers |
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| QU Jun-xiao,ZENG Qing-lei,LI Chun-xia,FENG Ji-hong,XU Guang-hua.Tracing study on spontaneous HBV YMDD mutation in chronic HBV carriers[J].Chinese Hepatology,2011,16(1):17-19. |
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| Authors: | QU Jun-xiao ZENG Qing-lei LI Chun-xia FENG Ji-hong XU Guang-hua |
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| Institution: | .(Department of Infectious Diseases of The Affiliated Hospital of Yan′an University,Yan′an 716000,China) |
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| Abstract: | Objective To investigate the diversification of spontaneous HBV YMDD motif mutation in chronic HBV carriers in two years.Methods One hundred and three cases of chronic HBV carriers who were received antivirus therapy were enrolled in the study.The diversification of HBV DNA,HBV M,liver function and YMDD mutations were observed at baseline,1 year and 2 years after baseline respectively.Results Among the 103 chronic HBV carriers,spontaneous YMDD variants were detected in 27 cases(26.21%),and after 2-year obse... |
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| Keywords: | chronic HBV carrier Spontaneous YMDD Motif Mutation Tracing study |
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