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| 卵巢癌单抗·脂质体·阿霉素对荷瘤裸鼠导向治疗的研究 | |
| 引用本文： | 李文锦,钱和年,聂松青. 卵巢癌单抗·脂质体·阿霉素对荷瘤裸鼠导向治疗的研究[J]. 北京大学学报(医学版), 1992, 0(3) |
| 作者姓名： | 李文锦 钱和年 聂松青 |
| 作者单位： | 北京医科大学人民医院妇科肿瘤研究室(李文锦，钱和年)，北京医科大学生物物理教研室(聂松青) |
| 摘 要： | 本文用自制卵巢上皮癌单抗COC166-9与包载阿霉素的脂质体结合制备成免疫脂质体MLA。通过应用MLA对24只荷人卵巢癌裸鼠进行导向治疗,初步结果证明,导向治疗效果明显高于非导向治疗,具有研究价值和临床应用前景。 |
| 关 键 词： | 卵巢癌 单抗 脂质体 阿霉素 导向治疗 |
THE STUDY OF TARGET THERAPY BY MONOCLONAL ANTIBODY AGAINST OVARIAN CARCINOMA CONJUGATED WITH LIPOSOME AND ADRIAMYCIN |
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| Abstract: | Conjgates of monoclonal antibody (MAb) and adriamycin entrapped in liposomes (MLA) wereprepared by COC 166-9. The MAb against ovarian serous adenocarcinoma generated in our laboratory.Target therapies with MLA were done in 24 nude mice bearing human ovarian carcinoma in 5 diffe-rent groups. The results demonstrated that MLA group presented the best therapeutic effect than allthe other groups which gave a very helpful clue to clinical target therapy of ovarian carcinoma in thefuture. |
| Keywords: | Ovarian carcinoma Monoclonal antibody Liposome Adriamycin Target therapy |
| 本文献已被 CNKI 等数据库收录！ | |