解析COMT基因Met多态与子宫内膜异位症的关系

目的探讨COMT基因Met多态与子宫内膜异位症的相关性。方法该研究选择的观察组对象60例,均为该院收治的子宫内膜异位症者,与40例对照组非内异症及腺肌病的女性采用PCR-RFLP法进行COMT基因分型,回顾相关资料。结果观察组野生纯和型(G/G)基因型、突变杂合型(G/A)基因型、突变纯合型基因型频率与对照组比较差异无统计学意义(P>0.05)。两组G等位基因频率(观察组72.9%,对照组27.1%)与A等位基因频率(观察组70%,对照组30%)比较差异无统计学意义(P>0.05)。COMTC/G(OR=1)、G/A(OR=0.516,95%CI为0.186-1.442)、A/A(OR=0.451,95%CI=0.166-1.234),3种基因型相对危度分析差异无统计学意义(P>0.05)。提示子宫内膜异位症的发生与COMT基因多态无明显相关性。结论子宫内膜异位症的发生与COMT基因Met多态无相关性,在临床治疗中可作为参考依据。

Resolution Met COMT gene Polymorphism and Endometriosis-associated

objective Explore Met COMT gene polymorphism and endometriosis-associated dependencies.M ethods Observer Group in this study,60 cases endometrium of patients,were admitted to our hospital between June 2010 to June 2012.With 40 cases in the control group of non-exclusive and adenomyosis female had COMT gene type using the PCR-RFLP method,Recallrelated information.Results Observer Group pure and wild-type（G/G） of hybrid genotypes,mutations（G/A） genotypes,homozygous mutation frequencies compared with the control group difference was not obvious meaning（P〈0.05）.Two sets of g allele frequen cies（Observer Group 72.9%,control 27.1%） with the a allele frequency（Observer Group 70%,control group 30%） are not significantly different（P〉0.05）.COMT C/G（OR=1）,G/A（OR=0.516,95%CI 0.186-1.442）,A/A（OR=0.451,95%CI=0.166-1.234）,three genotypes relative risk analysis no significant differences（P〉0.05）.Prompting the endometrium of patients with no obvious correla tion between the polymorphism of COMT gene.C onclusion Endometrium of patients and no correlation between polymorphism of COMT gene Met,could serve as a reference in clinical treatment.