IgE-mediated anaphylactic reaction to purified and recombinant factor VIII in a patient with severe haemophilia A |
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| Authors: | J G KADAR J SCHUSTER† N HUNZELMANN† |
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| Institution: | 1. Outpatient‐Clinic and Laboratory for Transfusion Medicine;2. Department of Dermatology, University of Cologne, K?ln, Germany |
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| Abstract: | We report a 51-year-old patient with severe haemophilia A developing a severe life-threatening anaphylactic reaction to recombinant factor VIII (rFVIII). Anaphylactic reactions are a rare but well-known side effect of FVIII products. The nature of these reactions could not be clarified as previous studies failed to demonstrate a specific IgE response. Here, we could prove a grade 3 anaphlyactic reaction as an IgE-mediated response to rFVIII for the first time by Western blotting. |
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| Keywords: | allergy bleeding disorder IgE-mediated reaction inhibitors recombinant |
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