盐酸青藤碱二元醇质体的制备及其体外性质研究

目的 制备盐酸青藤碱二元醇质体,筛选出较优处方,并对其体外性质进行考察. 方法 采用醇注入法制备以丙二醇和乙醇为柔软剂的盐酸青藤碱二元醇质体；以包封率为评价指标,通过正交实验优化处方；对其形态、Zeta电位、粒径及体外释药特征进行考察. 结果 较优处方制备的盐酸青藤碱二元醇质体外形圆整,平均包封率为(35.43 ±0.53)％,Zeta电位为(-5.87±0.06)mV,粒径为(391.6±25.6)nm,体外累积释药百分率Q与时间的关系符合一级速度方程:Q=0.085t+0.739,r =0.995 8. 结论 盐酸青藤碱二元醇质体制备简单,具有一定的缓释特性,值得进一步研究.

Investigation on preparation and in vitro properties of sinomenine hydrochloride binary ethosomes

Objective To screen the optimal formulation for preparing sinomenine hydrochloride binary ethosomes and to explore its properties in vitro.Methods The binary ethosomes were prepared by ethanol injection method with ethanol and propylene glycol as the softeners.An orthogonal test was used to optimize the formulation with entrapment efficiency as the index.The shape,Zeta potential,size and in vitro drug release were analyzed.Results The prepared binary ethosomes were spherical in shape.The average entrapment efficiency of the optimal formulation was(35.43±0.53)% with Zeta potential of-(5.87±0.06)mV and mean size of(391.6±1.70)nm.The drug release in vitro was fitted the first-order equation:Q=0.085t+0.739,r=0.9958.Conclusion Sinomenine hydrochloride binary ethosomes are easy to be prepared and have a sustained release property in vitro.