普拉洛芬联合氟米龙对LASEK术后反应的疗效评价

目的:评价普拉洛芬滴眼液在准分子激光上皮瓣下角膜磨镶术（LASEK）术中的临床应用价值。 方法:选取行LASEK治疗的300例600眼近视患者，随机分为两组，每组150例300眼。对照组术后单用氟米龙滴眼液点眼，试验组术后联合应用普拉洛芬与氟米龙滴眼液点眼，观察两组术后角膜刺激症状及术后并发症haze发生情况。 结果:治疗组的角膜刺激症状在术后3d内较对照组明显减轻，两组间比较具有显著性差异（P<0.05），而术后第5~7d两组间比较差异无统计学意义（P>0.05）。术后两组不同时期haze发生情况，试验组明显低于对照组，两组间比较差异有统计学意义（P<0.05）。术后对照组发生激素性高眼压12例(4.0%），试验组发生4例（1.3%），两组间比较差异具有统计学意义（P=0.043）。 结论:普拉洛芬与氟米龙滴眼液联合应用能显著减轻LASEK术后炎症反应，缓解术后早期角膜刺激症状，有效预防和控制haze以及降低术后激素性高眼压的发生。

Effect evaluation of Pranoprofen combined with Fluorometholone eyedrops on postoperative reaction of LASEK

AIM:To investigate the application of Pranoprofen eyedrops in laser epithelial keratomileusis(LASEK) and its clinical value. METHODS:Totally 300 cases (600 eyes) which had undergone LASEK were examined and randomly divided into two groups, each group had 150 cases (300 eyes). The control group was given Fluorometholone eye drops, experimental group combined with Pranoprofen eye drops. Corneal irritation and haze were compared and observed between these two groups. RESULTS:In three days after operation, the corneal irritation in the experimental group was significantly reduced compared with the control group (P<0.05), but there was no significant difference in five to seven days after operation (P>0.05). The occurrence of haze in the experimental group was significantly lower than the control group in different stages, and there were significant differences between the two groups in each stage(P<0.05). The incidence of steroid-induced ocular hypertension was 12 cases (4%) in control group and 4 cases (1.3%) in experimental group, and there was significant difference between the two groups (P=0.043). CONCLUSION: The combined use of fluorometholone and Pranoprofen can significantly reduce the inflammatory response, alleviate corneal irritation at early stage after LASEK, effectively prevent and control the occurrence of haze, and reduce the incidence of steroid-induced ocular hypertension after the operation.