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Haploidentical peripheral blood stem cell infusion in combination with chemotherapy for acute myeloid leukaemia in elderly patients |
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| Authors: | D. C. Bishop A. J. Johnston J. M. W. Kwan V. Antonenas D. J. Gottlieb |
| Affiliation: | 1. Department of Haematology, Westmead Hospital, , Sydney, New South Wales, Australia;2. Sydney Medical School, University of Sydney, , Sydney, New South Wales, Australia;3. Blood and Marrow Transplant Service, Westmead Hospital, , Sydney, New South Wales, Australia;4. Sydney Cellular Therapies Laboratory, Westmead Hospital, , Sydney, New South Wales, Australia;5. Department of Medicine, Westmead Hospital, , Sydney, New South Wales, Australia |
| Abstract: | Elderly patients with acute myeloid leukaemia (AML) have a poor prognosis with standard chemotherapy. Two elderly AML patients treated with infusion of family‐derived partially human leukocyte antigen (HLA)‐matched peripheral blood stem cells following each cycle of chemotherapy entered morphological complete remission without graft versus host disease or major toxicity. Our results support this as a non‐toxic approach for inducing a graft versus leukaemia effect in patients not suitable for allogeneic transplantation. Additional resources required for donor assessment and harvest may be reduced by using banked partially HLA‐matched mononuclear cells from unrelated donors. |
| Keywords: | acute myeloid leukaemia hematopoietic stem cell transplantation antineoplastic combined chemotherapy protocol/therapeutic use adoptive cellular immunotherapy aged |