Non‐equilibrium atmospheric pressure plasmas modulate cell cycle‐related gene expressions in melanocytic tumors of RET‐transgenic mice |
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| Authors: | Ichiro Yajima Machiko Iida Mayuko Y. Kumasaka Yasuhiro Omata Nobutaka Ohgami Jie Chang Sahoko Ichihara Masaru Hori Masashi Kato |
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| Affiliation: | 1. Unit of Environmental Health Sciences, Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, , Kasugai, Aichi, Japan;2. Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, , Nagoya, Aichi, Japan;3. Graduate School of Regional Innovation Studies, Mie University, , Tsu, Japan;4. Department of Electrical Engineering and Computer Science, Graduate School of Engineering, Nagoya University, , Nagoya, Japan |
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| Abstract: | ![]()
The incidence of cutaneous malignant melanoma is increasing at a greater rate than that of any other cancer in the world. However, an effective therapy for malignant melanoma has not been established. Recently, some studies have shown an antitumor effect of non‐equilibrium atmospheric pressure plasmas (NEAPPs) in vitro. Here, we examined the in vivo effect of NEAPP on cell cycle regulators, key elements for malignant transformation, in spontaneously developed benign melanocytic tumors in a hairless animal model. NEAPP irradiation decreased expression levels of cell cycle promoters, Cyclin D1, E1 and E2, and increased expression level of a cell cycle repressor, p27KIP1. Cyclin D1, E1 and E2 and p27KIP expression levels were associated with malignant transformation of the benign tumor in the animal model. Our results suggest that NEAPP irradiation suppresses malignant transformation of a benign melanocytic tumor via control of the expression levels of cell cycle regulators. |
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| Keywords: | cell cycle
RET
melanoma non‐equilibrium atmospheric pressure plasma |
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