Four novel HLA alleles,DRB1*04:11:03, DRB1*10:05, DRB1*15:94 and DRB1*16:22, identified in Brazilian individuals |
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| Authors: | R. A. Fabreti‐Oliveira E. Nascimento C. K. F. Oliveira E. M. G. Vale B. Vilela M. A. Santos |
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| Affiliation: | 1. Departamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, , Belo Horizonte, MG, Brazil;2. Departamento da Ciência da Computa??o, Universidade Federal de Minas Gerais, , Belo Horizonte, MG, Brazil;3. IMUNOLAB – Laboratório de, Imunologia de Transplantes, , Belo Horizonte, MG, Brazil;4. Instituto de Ensino, Pesquisas e Clínica de Transplantes do Hospital Santa Casa de Belo Horizonte, , Belo Horizonte, MG, Brazil |
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| Abstract: | ![]()
Four novel human leucocyte antigen (HLA) class II alleles were identified by sequencing‐based typing (SBT) and analysis of the closest‐matching alleles from volunteer subjects from the Brazilian Bone Marrow Donor Register (REDOME, Brazil). The new HLA alleles discovered include DRB1*04:11:03, DRB1*10:05, DRB1*15:94 and DRB1*16:22. Three of the novel alleles had single‐nucleotide substitution polymorphisms when compared to their most homologous allele. Of these, one harboured a single‐nucleotide polymorphism (SNP) identified as a silent substitution. |
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