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Syndrome‐associated soft tissue tumours |
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| Authors: | Cheryl M Coffin Jessica L Davis Scott C Borinstein |
| Institution: | 1. Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, , Nashville, TN, USA;2. Department of Anatomic Pathology, Laboratory Medicine, University of California at San Francisco, , San Francisco, CA, USA;3. Division of Pediatric Hematology/Oncology, Department of Pediatrics, Vanderbilt University School of Medicine, , Nashville, TN, USA |
| Abstract: | Soft tissue neoplasms may be associated with a variety of genetic disorders and malformation syndromes, especially when they arise in children, adolescents and early adulthood. This review summarizes the principal histopathological types of soft tissue tumours which occur in various syndromes, with an emphasis on pathological features, genetic aspects and considerations for the diagnostic pathologist. |
| Keywords: | desmoid‐type fibromatosis Gardner fibroma Li– Fraumeni syndrome malignant peripheral nerve sheath tumour malignant rhabdoid tumour neurofibroma neurofibromatosis type I rhabdomyosarcoma schwannoma |