阿托伐他汀早期强化抗炎作用对急性心肌梗死患者压力和化学反射敏感性的影响

目的：研究在急性心肌梗死（AMI）早期，阿托伐他汀强化治疗的抗炎作用对患者压力反射敏感性（BRS）和化学反射敏感性（ChRS）的影响。方法：将71例AMI患者分配至常规组（阿托伐他汀20mg／d，n=36）和强化组（阿托伐他汀40mg／d．n=35）。分别在入院时、用药后7d及14d检测血清超敏c反应蛋白（hsCRP）水平、白细胞介素6（IL-6）、血脂水平、BRS值、ChRS值及所有不良反应。结果：7d及14d时，两组hsCRP、IL-6水平较入院时均有明显降低；7d及14d时，强化组较常规组的hsCRP、IL-6水平均有显著降低。两组治疗后的血脂水平有显著改善，两组间差异无显著性。7d及14d时强化组BRS值、ChRS值较入院时均有明显改善；常规组仅于治疗后14d时BRS值、ChRS值有显著改善；与常规组相比，强化组治疗后BRS值、ChRS值的差异有显著性。结论：阿托伐他汀早期强化干预显著降低炎症因子水平，能更早地明显改善AMI的BRS、ChRS值。[著者文摘]

The Effect of Anti-Inflammation Action of Early Intensive Atorvastatin Therapy on Baroreflex Sensitivity and Chemoreflex Sensitivity After Acute Myocardial Infarction.

[Abstract] To study the beneficial influence of Anti-Inflammation Action of early Atorvastatin therapy with large dose on Baroreflex Sensitivity and Chemoreflex Sensitivity after acute myocardial infarction(AMI). 71patients,who were hospitalized AMI, were divided into two groups randomly,i.e, Atorvastatin 20mg/d and Atorvastatin 40mg/d groups.High sensitive c-reactive protein (hsCRP),interleukin6(IL-6) and Blood lipid were measured on the first day and the 7th,14th day, BRS、ChRS were measured on the third day and the 7th,14th day. Total harmful responses were followed by for two weeks.Results After 14 days the levels of cholesterol,HDL-c ,LDL-c,triglyceride in two groups have significant difference compared to those before therapy; the difference between the two groups was not significant. On the 7th and 14th day the levels of hsCRP and IL-6 in two groups have significant difference compared to those before therapy; the difference between two groups was significant. Ohly on the 14th day the levels of BRS and ChRS in Atorvastatin 20mg/d group are significantly better than those on the fifth day; on the 7th and 14th day the levels of BRS and ChRS in Atorvastatin 40mg/d group are significantly better than those on the fifth day; the difference between two groups was significant.Conclusion The early intensive atorvastatin therapy is effective and safe,it can am significantly induce the levels of hsCRP 、L-6，and earlier significantly improve the levels of BRS and ChRS after AMI.