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| E-钙黏蛋白在三阴性乳腺癌组织中的表达 | |
| 引用本文： | 孙弢,姚宇锋,龚建平,秦建伟,唐金海. E-钙黏蛋白在三阴性乳腺癌组织中的表达[J]. 河南肿瘤学杂志, 2014, 0(1): 8-10 |
| 作者姓名： | 孙弢 姚宇锋 龚建平 秦建伟 唐金海 |
| 作者单位： | [1]滁州市第一人民医院普外科,安徽滁州239000 [2]江苏省肿瘤医院普外科,江苏南京210009 |
| 摘 要： | 目的检测E-钙黏蛋白（E-cad）在三阴性乳腺癌（TNBC）组织中的表达，探讨其评估预后的价值。方法采用免疫组化方法检测经手术病理确诊的147例TNBC患者的E—cad的表达情况。结果TNBC组织中E．cad的阳性率为32％（47／147）。E-cad阳性表达与肿块大小、组织学分级、淋巴结转移均有关（P均〈0．05）。E—cad阴性患者的5a总生存率和无病生存率均低于E-cad阳性患者（61％vs89％，27％vs65％，P均〈0．05）。结论TNBC中E-cad阳性者预后好，上调E—cad表达可能成为TNBC新的治疗手段。 |
| 关 键 词： | E-钙黏蛋白 乳腺肿瘤 预后 |
Expression of E-cadherin in the Triple Negative Breast Cancer |
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| Sun Tao,Yao Yufeng,Gong Jianpmg,Qin Jianwei,Tang Jinhai. Expression of E-cadherin in the Triple Negative Breast Cancer[J]. Henan Journal of Oncology, 2014, 0(1): 8-10 | |
| Authors: | Sun Tao Yao Yufeng Gong Jianpmg Qin Jianwei Tang Jinhai |
| Affiliation: | 1. Department of General Surgery, the First People＇ s Hospital of Chuzhou, Chuzhou 239000, China ; 2. Department of General Surgery, Jiangsu Cancer Hospital, Nanjing 210009, China) |
| Abstract: | Objective To investigate the expression and the prognostic value of E-cadherin （E-cad）in the triple negative breast cancer （TNBC）. Methods Immunohistochemical staining was used to detect the expression of E- cad in the 147 cases of TNBC. Results The positive rate of E-cad expression was 32% （47/147） in the TNBC. E- cad was significantly correlated with the tumor volume, histological grade and lymph node metastasis （ P 〈 0.05 ）. The follow-up showed that the 5-year disease-free survival and overall survival rates of the patients with the negative E-cad expression were lower than those of the patients with positive E-cad expression （61% vs 89% , 27% vs 65% ,P 〈 0.05）. Conclusion TNBC with positive E-cad has good prognosis, Up-regulation of E-cad may become a therapeutic tool for TNBC. |
| Keywords: | E-cadherin breast neoplasms prognosis |
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