| 葶苈子对昆明种小鼠移植H22肝癌移植瘤抑瘤作用的研究 |
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| 引用本文： | 马梅芳,李芳. 葶苈子对昆明种小鼠移植H22肝癌移植瘤抑瘤作用的研究[J]. 中医药学刊, 2014, 0(2): 385-386 |
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| 作者姓名： | 马梅芳 李芳 |
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| 作者单位： | [1]枣庄市食品药品检验中心,山东枣庄277102 [2]陕西省中医药研究院,陕西西安710003 |
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| 基金项目： | 基金项目：枣庄市科技发展计划项目（201039） |
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| 摘 要： | 目的：探讨不同品种葶苈子对H22荷瘤小鼠动物模型的影响。方法：观察不同品种葶苈子对H22荷瘤小鼠肿瘤的抑瘤率、生命延长率、肝体比、肺体比、胸腺指数、脾指数以及用药前后的体重变化等指标的影响。结果：南北葶苈子的抑瘤作用与荷瘤对照组比较有显著性差异（P〈0．05）；南北葶苈子与顺铂合用组与单用顺铂组比较有极显著性差异（P〈0．01）。结论：葶苈子具有一定的抑瘤作用；与顺铂合用，可以明显对抗顺铂对肺的损伤和对机体的免疫抑制作用，具有显著的减毒增效作用。
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| 关 键 词： | 葶苈子 肿瘤 小鼠 |
Study on Anti -tumor Effects of Tinglizi on Mice Bearing H22 Tumor |
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| MA Meifang,LI Fang. Study on Anti -tumor Effects of Tinglizi on Mice Bearing H22 Tumor[J]. Study Journal of Traditional Chinese Medicine, 2014, 0(2): 385-386 |
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| Authors: | MA Meifang LI Fang |
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| Affiliation: | 1. Zaozhuang Institute of Food and Drug Control, Zaozhuang 277102, Shandong, China; 2. Shanxi Provincial Academy of TCM, Xi＇ an 710003, Shanxi, China) |
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| Abstract: | Objective ： To investigate anti - tumor effects of Tinglizi of different varieties on mice bearing H22 Tumor. Method： Model of transplanting tumor of H22 sarcoma was founded to observe anti - tumor rate, prolonging survival rate, liver- body ratio,lung -body ratio, chest gland - -body ratio and spleen -body ratio of Tinglizi. Result：Tinglizi groups had difference compared with collate group（P 〈 0.05 ）. Tinglizi combined with DDP groups had significant difference（P 〈 0.01 ）. Conclusion ：Tinglizi has certain restrain tumor effect, indicating Tinglizi could reduce damn of body by DDP, protect immunity of body, depress side - effect of DDP, increase the effect and reduce the poisonous action of DDP. |
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| Keywords: | Tinglizi tumor mice |
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