| 乳腺肿瘤微环境靶向治疗的研究进展 |
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| 引用本文： | 杨云松,江一舟,胡 欣,邵志敏. 乳腺肿瘤微环境靶向治疗的研究进展[J]. 中国癌症杂志, 2019, 29(12): 977-984. DOI: 10.19401/j.cnki.1007-3639.2019.12.010 |
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| 作者姓名： | 杨云松 江一舟 胡 欣 邵志敏 |
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| 作者单位： | 复旦大学附属肿瘤医院乳腺外科，复旦大学上海医学院肿瘤学系，上海 200032 |
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| 摘 要： | 肿瘤细胞周围的免疫细胞、成纤维细胞、内皮细胞及其驱动分子等组成的肿瘤微环境可以调控肿瘤细胞的生长、侵袭和转移，因此在针对肿瘤细胞进行治疗的同时靶向肿瘤微环境成为乳腺癌综合治疗的新策略。对乳腺肿瘤微环境中的预测标志物，以及如何靶向肿瘤微环境增加抗乳腺肿瘤治疗的疗效进行了综述，为乳腺癌的治疗提供新的思路。
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| 关 键 词： | 乳腺癌 肿瘤微环境 免疫治疗 |
Research progress of breast tumor microenvironment-targeted therapy |
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| YANG Yunsong,JIANG Yizhou,HU Xin,SHAO Zhimin. Research progress of breast tumor microenvironment-targeted therapy[J]. China Oncology, 2019, 29(12): 977-984. DOI: 10.19401/j.cnki.1007-3639.2019.12.010 |
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| Authors: | YANG Yunsong JIANG Yizhou HU Xin SHAO Zhimin |
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| Affiliation: | Department of Breast Surgery, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China |
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| Abstract: | Tumor microenvironment is composed of immune cells, fibroblasts and endothelial cells, and proliferation, invasion and metastasis of tumor cells are regulated by tumor microenvironment. Therefore, targeting both tumor cells and the surrounding microenvironment should be included in the comprehensive treatment of breast cancer. In this review, we summarized the prognostic value of the tumor microenvironment in breast cancer and how to increase the therapeutic effect of anti-cancer therapy through addition of anti-microenvironment therapy. |
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| Keywords: | Breast cancer Tumor microenvironment Immunotherapy |
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