|
|||||
|
|
| 甲状腺球蛋白抗体测定在分化型甲状腺癌131I治疗中的临床意义 | |
| 引用本文： | 张 娜,林岩松,梁 军. 甲状腺球蛋白抗体测定在分化型甲状腺癌131I治疗中的临床意义[J]. 中国癌症杂志, 2019, 29(6): 452-456. DOI: 10.19401/j.cnki.1007-3639.2019.06.009 |
| 作者姓名： | 张 娜 林岩松 梁 军 |
| 作者单位： | 1. 青岛大学附属医院肿瘤科，山东 青岛 266003 ；2. 中国医学科学院北京协和医学院北京协和医院核医学科，北京 100730 ；3. 北京大学国际医院肿瘤科，北京 102206 |
| 基金项目： | 国家自然科学基金资助项目（81571714；81771875）。 |
| 摘 要： | 甲状腺球蛋白（thyroglobulin，Tg）是分化型甲状腺癌（differentiated thyroid carcinoma，DTC）患者治疗后随访的主要血清标志物，Tg的测定会受到甲状腺球蛋白抗体（thyroglobulin antibody，TgAb）的影响，限制了Tg作为肿瘤标志物在DTC随访中的作用。因此，有关TgAb阳性患者的随访一直是临床工作中的难题，有研究指出TgAb可以作为替补肿瘤标志物用于DTC的监测，但有关TgAb与DTC治疗后疾病状态与预后间的关系尚存争议。主要就TgAb在DTC患者131I治疗中的临床意义进行综述，以期为TgAb阳性患者的临床决策提供更多依据。 |
| 关 键 词： | 甲状腺球蛋白抗体 分化型甲状腺癌 131I治疗 临床意义 |
The clinical significance of thyroglobulin antibody measurement in 131I therapy of differentiated thyroid carcinoma |
|
| ZHANG Na,LIN Yansong,LIANG Jun. The clinical significance of thyroglobulin antibody measurement in 131I therapy of differentiated thyroid carcinoma[J]. China Oncology, 2019, 29(6): 452-456. DOI: 10.19401/j.cnki.1007-3639.2019.06.009 | |
| Authors: | ZHANG Na LIN Yansong LIANG Jun |
| Affiliation: | 1. Department of Oncology, the Affiliated Hospital of Qingdao University, Qingdao 266003, Shandong Province, China; 2. Department of Nuclear Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China; 3. Department of Medical Oncology, Peking University International Hospital, Beijing 102206, China |
| Abstract: | Serum thyroglobulin (Tg) is a major tumor marker for follow-up after treatment of patients with differentiated thyroid carcinoma (DTC). However, the accuracy of Tg measurement is interfered by thyroglobulin antibody (TgAb), limiting the predictive value of Tg. Therefore, the follow-up of DTCs with positive TgAb remains a clinical puzzlement. Some researchers have proposed that TgAb could also serve as a surrogate tumor marker for the monitoring of DTC, but it remains controversial over the relationship between TgAb and disease status or prognosis after treatment. This article reviewed the clinical significance of TgAb measurement in 131I therapy of DTC, in order to provide more evidence for clinical decision making in patients with positive TgAb. |
| Keywords: | Thyroglobulin antibody Differentiated thyroid cancer Radioactive iodine therapy Clinical significance |
| 点击此处可从《中国癌症杂志》浏览原始摘要信息 | |
| 点击此处可从《中国癌症杂志》下载全文 | |