Phenotypic and genomic characterization of the antimicrobial producer Rheinheimera sp. EpRS3 isolated from the medicinal plant Echinacea purpurea: insights into its biotechnological relevance |
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Affiliation: | 1. Dept of Biology, University of Florence, Via Madonna del Piano 6, I-50019 Sesto F.no, FI, Italy;2. Center for Integrative Medicine, Careggi University Hospital, University of Florence, Florence, Italy;3. Department of Surgery and Translational Medicine, University of Florence, Florence, Italy;4. Department of Medical Biotechnologies, University of Siena, Siena, Italy;5. Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy;6. Clinical Microbiology and Virology Unit, Careggi University Hospital, Florence, Italy;7. Don Carlo Gnocchi Foundation, Florence, Italy;1. Department of Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada V6T 2B5;2. Medical Department, A. Vogel Bioforce AG, Roggwil TG, Switzerland;1. Key Laboratory of Bio-resource and Eco-environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610064, China;2. Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China;1. Department of Biology, University of Florence, Via Madonna del Piano 6, I-50019 Sesto Fiorentino, Florence 50019, Italy;2. Department of Chemistry Ugo Schiff, University of Florence, Via Ugo Schiff 6, I-50019 Sesto Fiorentino, Florence 50019, Italy;3. Il giardino delle Erbe, “Augusto Rinaldi Ceroni”, Casola Valsenio, Ravenna, Italy;4. Centre for Integrative Medicine, Careggi University Hospital, University of Florence, Florence, Italy;5. Department of Pharmacy, University of Pisa, Via Bonanno Pisano 6, I-56126 Pisa, Italy;1. Department of Agronomy and Plant Breeding, Faculty of Agriculture, Yasouj University, Yasouj, Iran;2. Department of Agronomy and Plant Breeding, Faculty of Agriculture, Yasouj University, Yasouj, Iran;3. Research Division of Natural Resources, Isfahan Agricultural and Natural Resources Research and Education Center, AREEO, Isfahan, Iran;1. PhD. student, Agronomy, and Plant Breeding Department, Yasouj University, Yasouj, Iran;2. Associate Professor, Agronomy, and Plant Breeding Department, Yasouj University, Yasouj, Iran;3. Soil and Water Research Department, Fars Agricultural and Natural Resources Research and Education Center, AREEO, Shiraz, Iran |
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Abstract: | In recent years, there has been increasing interest in plant microbiota; however, despite medicinal plant relevance, very little is known about their highly complex endophytic communities. In this work, we report on the genomic and phenotypic characterization of the antimicrobial compound producer Rheinheimera sp. EpRS3, a bacterial strain isolated from the rhizospheric soil of the medicinal plant Echinacea purpurea. In particular, EpRS3 is able to inhibit growth of different bacterial pathogens (Bcc, Acinetobacter baumannii, and Klebsiella pneumoniae) which might be related to the presence of gene clusters involved in the biosynthesis of different types of secondary metabolites. The outcomes presented in this work highlight the fact that the strain possesses huge biotechnological potential; indeed, it also shows antimicrobial effects upon well-described multidrug-resistant (MDR) human pathogens, and it affects plant root elongation and morphology, mimicking indole acetic acid (IAA) action. |
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Keywords: | Endophytes Antibiotic resistance Antibiotic production Biotechnological applications Genome analysis |
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