A mouse monoclonal antibody against a polymorphic determinant in a defined subset of DR molecules |
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| Authors: | M C Mazzilli N Tanigaki I Cascino S Costanzi Porrini S Trabace S Cappellacci L Testa E Gandini |
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| Affiliation: | 1. Guangxi Key Laboratory of Automobile Components and Vehicle Technology, School of Mechanical and Automotive Engineering, Guangxi University of Science & Technology, Liuzhou 545006, China;2. National Engineering Laboratory for Modern Materials Surface Engineering Technology, Institute of New Materials, Guangdong Academy of Science, Guangzhou 510651, China;3. Suzhou Thermal Engineering Research Institute Co. Ltd., Guangdong Province, Shenzhen 518000, China;4. School of Materials Science and Engineering, Northwestern Polytechnical University, Xi''an 710021, China;5. AECC Aviation Power Co. Ltd., Xi''an 710003, China;6. AECC Sichuan Gas Turbine Establishment, Chengdu 610500, China |
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| Abstract: | ![]()
The hybridoma technique was used to produce a mouse monoclonal antibody, designated as XI 21.4, which belongs to the IgG2a class. It is active in complement-dependent cytotoxicity and detects a B-cell antigenic determinant associated with DR1, DR4, DRw10, and, possibly, DRw9. Microfingerprinting of the immunoprecipitate from a homozygous DR4 cell line shows a typical alpha DR pattern and a beta pattern coinciding with that of DR4 molecules. |
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