Antimalarial Activity of the Novel Quinoline/6‐Thiopurine Conjugate in Gallus gallus Linnaeus,Infected Experimentally by Plasmodium (Novyella) juxtanucleare |
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| Authors: | Usha Vashist Rafael Carvalhaes Marta D’agosto Adilson David Da Silva |
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| Affiliation: | 1. Departamento de Biologia, Instituto de Ciências Biológicas, Universidade Federal de Juiz de Fora, Juiz de Fora, M.G. 36036–900, Brazil;2. Departamento de Quimica, Instituto de Ciências Exatas, Universidade Federal de Juiz de Fora, Juiz de Fora, M.G. 36036–900, Brazil |
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| Abstract: | ![]()
This study aimed to evaluate the 4‐(6′‐thiopurine)‐7‐chloroquinoline, a novel quinoline/6‐thiopurine conjugate, for the treatment of Gallus gallus experimentally infected with Plasmodium juxtanucleare, an avian malaria agent. The avian group treated with 4‐(6′‐thiopurine)‐7‐chloroquinoline showed a significative parasite clearance and maintained a low level of parasitaemia, when compared with the untreated control group and to the chloroquine treated avian group. |
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| Keywords: | antimalarials avian malaria chloroquinoline quinoline/6‐thiopurine conjugate |
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