黄芪对大鼠酒精性肝病肝组织ICAM-1表达的影响

目的探讨黄芪对大鼠酒精性肝病肝组织ICAM-1的影响。方法将36只大鼠随机分为3组(每组12只):正常对照组(简称对照组)、酒精性肝病模型组(简称模型组)、酒精性肝病黄芪治疗组(简称治疗组)。观察各组肝组织ICAM-1的表达及肝组织形态学改变。结果酒精性肝病模型组肝组织ICAM-1的表达明显增强,与正常对照组有显著性差异(P<0.01);酒精性肝病黄芪治疗组与酒精性肝病模型组比较肝组织ICAM-1的表达明显减弱(P<0.01),肝组织损害减轻(P<0.01)。结论黄芪对酒精性肝病有防治作用,其机理可能与其抑制肝细胞中ICAM-1的的表达有关。

The Effect of Radis Astragali on the Expression Level of Intercellular Adhesion Molecule-1(ICAM-1) in Liver with Alcoholic Liver Disease in Rats

Objective To investigate the effect of Radis Astragali on the expression of intercellular adhesion molecule-1(ICAM-1) in liver with alcoholic liver disease in rats.Methods 36 cases of rats were randomly into three groups:control group,alcoholic liver disease group,alcoholic liver disease treatment group,12 cases in each.The morphological changes and ICAM-1 expression level in liver were observed.Results The expression level of ICAM-1 in alcoholic liver disease group was higher than that in control group(P<0.01),the structure of liver tissue was impaired(P<0.01).The expression level of ICAM1 in alcoholic liver disease treatment group was lower than that in alcoholic liver disease group(P<0.01),the structure injury in the liver tissue was alleviated(P<0.01).Conclusion Radis Astragali has satisfactory effect on experimental alcoholic liver disease,the mechanism may be corelated with its inhibition on ICAM-1 in liver tissue.