八宝丹胶囊治疗黄疸型病毒性肝炎临床研究

目的观察八宝丹胶囊治疗黄疸型病毒性肝炎的临床疗效及对肝功能等的影响。方法将112例黄疸型病毒性肝炎患者随机分为2组,对照组56例予西医常规治疗,治疗组56例在对照组治疗基础上加八宝丹胶囊。2组均2周为1个疗程,连续3个疗程。观察2组治疗后主要临床症状、体征改善情况;检测肝功能主要指标[包括丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）、血清总胆红素（TBiL）、γ谷氨酰转肽酶（γ-GT）及总胆汁酸（TBA）]变化情况;观察TBiL复常时间及复常率。结果治疗组总有效率92.9%,对照组总有效率78.6%,2组总有效率比较差异有统计学意义（P〈0.05）,治疗组疗效优于对照组。治疗组尿黄、肝区叩痛、舌苔黄腻及舌质紫黯改善例数优于对照组（P〈0.05）。2组治疗后ALT、AST、TBiL、γ-GT及TBA与本组治疗前比较均明显降低（P〈0.05）,且治疗组治疗后TBiL及TBA低于对照组（P〈0.05）。治疗组TBiL复常时间（31.52±4.60）d,复常率80.4%;对照组TBiL复常时间（44.32±5.70）d,复常率60.7%,治疗组复常时间短于对照组（P〈0.05）,复常率高于对照组（P〈0.01）。结论八宝丹胶囊可明显改善黄疸型病毒性肝炎患者临床症状及肝功能,退黄效果佳,无毒副作用。

Clinical study of Babaodan capsules in treating jaundice viral hepatitis SHEN Meirong

Objective To observe clinical efficacy of jaundice viral hepatitis and effect of liver function treated by Babaodan capsules. Methods 112 viral hepatitis cases were randomized into two groups. The treatment group was treated with Babaodan capsules 0.6g tid in oral based on conventional treatment and conventional treatment were used only on control group. The course was two weeks in two groups. The improvement of main clinical symp- toms and signs were observed after three courses. The liver function （ ALT, AST, TRiL, γ- GT and TBA） and TBiLrecovery time and recovery rate were measured and observed. Results The total effective rate in trial group （92.9%） was higher than that in control group （78.6% , P 〈 0.05 ）. The improvement of symptom and sign in the treatment group was superior to that of the control group （P 〈 0.05）. ALT, AST, TBiL, γ-GT and TBA after treat- ment were obviously decrease as compared with those before treatment in groups （P 〈 0.05 ）. TBiL and TBA in treat- ment group were lower than those in control group after treatment （ P 〈 0.05 ）. TBiL recovery time and recovery rate in treatment group [ （ 31.52 ~ 4.60） d, 80.4% ） ] was superior to that in control group [ （44.32 ± 5.70） d, 60.7 %, P 〈 0.05, P 〈 0.01 ） ]. Conclusion Babaodan capsules were good at jaundice eliminating, liver enzymes decrea- sing, chotestasis improving and no side effect.