| 顺铂化疗联合用药的增效减毒作用研究进展 |
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| 引用本文： | 杨红,龚灿,王长虹,齐聪.顺铂化疗联合用药的增效减毒作用研究进展[J].中国药师,2015(5):836-840. |
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| 作者姓名： | 杨红 龚灿 王长虹 齐聪 |
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| 作者单位： | 上海中医药大学附属曙光医院妇科 上海201210；;上海中医药大学中药研究所，中药标准化教育部重点实验室；上海应用技术学院化学与环境工程学院;上海中医药大学中药研究所，中药标准化教育部重点实验室；;上海中医药大学附属曙光医院妇科 |
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| 基金项目： | 国家自然科学基金项目（编号：81173291），上海市教委创新团队课题（2009） |
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| 摘 要： | 摘 要 顺铂在临床上应用于多种肿瘤的治疗，也会引起广泛的不良反应如肾毒性、肝毒性、耳毒性等，限制了其临床应用，因此临床上主张联合用药以达到增效减毒的作用。本文概述了近些年来关于化学药及中药（中药成分、单味中药及中药复方）对顺铂的增效解毒作用方面的研究进展，为化疗药联合用药研究和临床给药方案的制定提供参考依据。
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| 关 键 词： | 顺铂 毒性 联合用药 增效解毒 |
| 收稿时间： | 2014/12/20 0:00:00 |
| 修稿时间： | 2015/1/22 0:00:00 |
Study Advances in Synergism and Detoxication of Drug Combination with Cisplatin in Chemotherapy |
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| Yang Hong,Gong Can,Wang Changhong and Qi Cong.Study Advances in Synergism and Detoxication of Drug Combination with Cisplatin in Chemotherapy[J].China Pharmacist,2015(5):836-840. |
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| Authors: | Yang Hong Gong Can Wang Changhong and Qi Cong |
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| Institution: | Department of Gynaecology, Shanghai Shuguang Hospital Affiliated with Shanghai University of Traditional Chinese Medicine, Shanghai 201210, China;;Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, the Ministry of Education (MOE) Key Laboratory for Standardization of Chinese Medicines;School of Chemical and Environmental Engineering, Shanghai Institute of Technology;Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, the Ministry of Education (MOE) Key Laboratory for Standardization of Chinese Medicines;;Department of Gynaecology, Shanghai Shuguang Hospital Affiliated with Shanghai University of Traditional Chinese Medicine |
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| Abstract: | ABSTRACT Cisplatin is effective in the treatment of various solid tumors. However, its clinical application is limited because of the severe side effects such as nephrotoxicity, hepatotoxicity, ototoxicity and so on. Drug combination is advocated in clinics for synergism and detoxication. In order to provide some referencs for the research of drug combination and clinical treatment regimen, the research advances in the synergism and detoxication of drug combination of cisplatin with chemicals/ traditional Chinese medicines in recent years are reviewed in the paper. |
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| Keywords: | Cisplatin Toxicity Drug combination Synergism and detoxication |
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