叶酸联合甲钴胺对尿毒症伴高同型半胱氨酸血症患者的影响

目的研究尿毒症患者血浆总同型半胱氨酸(tHcy)浓度及叶酸联合甲钴胺对其干预治疗的效果。方法采用荧光偏振免疫法检测60例尿毒症患者(治疗组)和40名健康人(正常对照组)血浆tHcy浓度,并对尿毒症伴高Hcy血症患者用叶酸联合甲钴胺进行干预治疗,治疗8wk后再次测定其血浆tHcy浓度。结果治疗前治疗组血浆tHcy浓度显著高于正常对照组(P<0.01);治疗后治疗组血浆tHcy浓度较治疗前明显下降(P<0.01)。结论尿毒症患者普遍存在高Hcy血症,叶酸联合甲钴胺可显著降低尿毒症患者血浆tHcy浓度。

Effects of Folic Acid Combined Methylcobalamin in the Treatment of the Patients that Are Uremia Accompanied by Hyperhomocysteinemia

OBJECTIVE:To study the plasma total homocysteine(tHcy)level in the uremia patients and to study the therapeutic effects of folic acid combined with methylcobalamin in the intervention treatment of uremia patients with homo-cysteinemia.METHODS:Levels of plasma tHcy of60uremia patients(treatment group)and40normal subjects(control group)were determined both before treatment and8weeks after intervention treatment with folic acid combined with methylcobal-amin.RESULTS:The plasma level of tHcy in uremia patients were significantly higher than that in the normal subjects(P< 0.01);while the plasma level of tHcy in the treatment group was significantly decreased after8weeks'treatment compared with that before treatment(P<0.01).CONCLUSIONS:Homocysteinemia is commonly found in the uremia patients.Folic acid combined with methylcobalamin can significantly reduce the plasma tHcy level in uremia patients with hyperhomocys-teinemia.