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Muscarinic Cholinergic Receptors of the Convulsive Strain (E1) Mouse

Authors:	Koichi Mori MD Seiichiro Fujita Kenji Kawaguchi Takashi Chikami Kyosuke Ohno Masaki Tsuji Hiroshi Onishi MD Sakae Yamagami MD Yukio Kawakita MD

Institution:	Department of Neuropsychiatry, Osaka City University Medical School, Osaka

Abstract:	Abstract: The biochemical characteristics of the muscarinic acetylcholine receptors were studied on the El strain mouse brain by the binding assay using ³H]l-quinuclydinyl benzylate. Scatchard analyses showed that the receptor density (B_max) of the hippocampus significantly decreased by 26.4% and the affinity (K_d) increased by 18.8% in El(+) compared to dd-Y. It is suggested that this hippocampal subsensitivity found in El(+) mouse might be strain-specific, because repeated megimide convulsions failed to produce the same down regulation.

Keywords:	El convulsion muscarinic receptor QNB hippocampal subsensitivity