| 雌二醇抗肝纤维化的实验性研究 |
| |
| 引用本文： | 李文斌,赵红宇. 雌二醇抗肝纤维化的实验性研究[J]. 肝胆外科杂志, 2008, 16(4): 311-313 |
| |
| 作者姓名： | 李文斌 赵红宇 |
| |
| 作者单位： | 大连市第二人民医院,大连,116037;黑龙江佳木斯大学 |
| |
| 摘 要： | 目的 探讨雌二醇对大鼠肝纤维化的影响及机制，以便对肝纤维化的治疗提供一种新的途径。方法 CCL4诱导大鼠肝纤维化动物模型，观察雌二醇对大鼠肝纤维化形成过程中血清AST、ALT、HA、CIV，以及肝组织胶原纤维沉积的影响。结果 雌二醇降低AST、ALT，HA、CIV及肝组织胶原纤维组织的沉积（P〈0．05）。结论 雌二醇有抑制大鼠肝纤维化进展的作用。
|
| 关 键 词： | 雌二醇 肝纤维化 胶原 |
THE STUDY OF THE SUPPRESSIVE EFFECTS OF ESTRADIOL ON LIVER FIBROSIS IN RATS |
| |
| LI Wen-bin,ZHAO Hong-yu. THE STUDY OF THE SUPPRESSIVE EFFECTS OF ESTRADIOL ON LIVER FIBROSIS IN RATS[J]. Journal of Hepatobiliary Surgery, 2008, 16(4): 311-313 |
| |
| Authors: | LI Wen-bin ZHAO Hong-yu |
| |
| Affiliation: | LI Wen-bin, ZHAO Hong-yu. (The third people hospital of Dalian,Dalian l16037 , China ) |
| |
| Abstract: | Objective To analyze the suppressive effects of estradiol on liver fihrotic rats, and then to investigate the suppressive effects of estradiol on liver fibrosis and prospect of clinic application. Methods Liver fibrosis was induced in rats by CCL4 administration, and was treated with estradiol. The expression of serum AST、ALT、 HA、CIV and hepatic collagen content were studied at the end of the experiment. Results Estradiol treatment suppress serum AST 、 ALT 、 HA 、 C IV and hepatic collagen content （ P 〈 0.05 ）. Conclusion Estradiol probably suppresses liver fihrotic rats. |
| |
| Keywords: | estradiol liver fibrosis collage |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
