晚期胃癌的腹腔热灌注联合全身静脉化疗临床疗效的观察

目的探讨合并腹腔和肝脑脏器转移的晚期胃癌患者,腹腔热灌注化疗联合全身静脉化疗的临床疗效。方法 23例晚期胃癌患者分为2组,实验组10例行腹腔热灌注化疗联合全身静脉化疗,对照组13例仅行单纯静脉化疗。比较2组患者的不良反应和并发症、生存情况、KPS评分情况。结果实验组总生存期较对照组延长,差异有统计学意义(P=0.003)。2组治疗前的生存质量KPS评分没有统计学差异(P=0.835),2组患者的不良反应及并发症发生率无统计学差异。结论合并腹腔和肝脑脏器转移的晚期胃癌患者,行腹腔热灌注化疗联合全身静脉化疗较单纯全身静脉化疗,可能有助于改善其生存质量和延长生存期。

Clinical observation on curative effect of hyperthermic intraperitoneal perfusion followed by intravenous chemotherapy in patients with advanced gastric cancer

Objective To evaluate the curative efficacy of hyperthermic intraperitoneal perfusion followed by intravenous chemotherapy in patients diagnosed as advanced gastric cancer. Methods 23 patients were assigned to 2 groups ,of which 10 patients treated with HIPEC followed by intravenous chemotherapy were treatment group,and 13 patients treated with intravenous chemotherapy alone were control group. The adverse reactions, complications, overall survival （OS） and KPS were compared between 2 groups. Results There was significant difference in OS（ P = 0. 003 ）. There was no significant difference between the two groups in KPS score （P = 0. 835 ）. No statistically significant differences were found in the adverse reactions and complications between the two groups （P 〉 0.05 ）. Conclusion HIPEC followed by intravenous chemotherapy leads to superior OS as compared with intravenous chemotherapy only.