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CSF IgH gene rearrangement analysis in isolated post-transplant lymphoproliferative disorder of the central nervous system |
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| Authors: | Joachim M. Baehring Marie-Louise Landry Dennis Cooper Pei Hui Serguei Bannykh |
| Affiliation: | (1) Department of Neurology and Neurosurgery, Yale University School of Medicine, 333 Cedar Street, TMP412, New Haven, CT 06510, USA;(2) Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA;(3) Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA;(4) Department of Pathology, Yale University School of Medicine, New Haven, CT, USA |
| Abstract: | Isolated post-transplant lymphoproliferative disorder (PTLD) of the central nervous system is rare and its diagnosis can be challenging. A biopsy is usually required in order to distinguish the disease from opportunistic infections. We present a case in whom immunoglobulin heavy chain gene rearrangement analysis of cerebrospinal fluid (CSF) was instrumental in establishing the diagnosis. |
| Keywords: | IgH CSF Post-transplant lymphoproliferative disorder Brain Lymphoma |
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