A型肉毒毒素在上面部除皱中的应用分析

目的:探讨A型肉毒毒素在上面部除皱治疗的应用方法。方法:用生理盐水将A型肉毒毒素稀释成25 u·mL-1分点注射,额横纹:10～14个注射点;鱼尾纹:3～4个注射点;眉间纹:4～5个注射点。结果:338例患者,注射后1～3 d可见皱纹减轻或消失,1～2周后出现最佳效果,可维持4～8个月,有效率达100%。1例发生休克,对症处理后好转;出现局部轻度水肿4例,局部瘀斑7例,眉型改变、眉下垂5例,以上并发症未做特殊处理,2～4周左右好转。结论:A型肉毒毒素注射除皱,虽然只能维持一定时间,但因有可逆性所以相对安全,是减少上面部动力性皱纹的有效方法。

Application of Botulinum Toxin A in the Treatment of Upper Facial Wrinkles

OBJECTIVE：To explore botulinum toxin A in the treatment of upper facial wrinkles. METHODS： The botulinum toxin A was diluted by normal saline into 25 u·mL-1 solution which was administered with multi-point injections at 10～14 points of frontal wrinkles, 3～4 points of fishtail lines and 4～5 points of glabellar frown lines. RESULTS： A total of 338 cases received treatment. The wrinkles relieved or disappeared after 1～3 days, and the optimal effect had been observed in 1～2 weeks after injections and maintained for 4～8 months. Effective rate was 100%. 1 case suffered from allergic shock and recovered after treatment; 4 cases suffered from mild edema, and 7 cases ecchymosis, 5 case ptosis of eyebrow. All theses complications had spontaneously improved in 2～4 weeks without any special treatment. CONCLUSION： Treatment of facial wrinkles with the injection of botulinum toxin A, while the effect of which only lasts for a period of time, is reversible and relatively safe to manage the upper facial wrinkles.