| 经熊去氧胆酸治疗妊娠期肝内胆汁淤积症孕妇血清胆汁酸谱分析 |
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| 引用本文： | 凌玲,刘兆明,邵勇,王富兰. 经熊去氧胆酸治疗妊娠期肝内胆汁淤积症孕妇血清胆汁酸谱分析[J]. 中国药房, 2011, 0(26): 2438-2440 |
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| 作者姓名： | 凌玲 刘兆明 邵勇 王富兰 |
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| 作者单位： | 重庆市红十字会医院;重庆医科大学附属第一医院; |
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| 基金项目： | 重庆市科学技术委员会自然科学基金(CSTC2007BB5278); 重庆市卫生局2009年度医学科研计划项目(2009-2-386) |
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| 摘 要： | 目的:探讨熊去氧胆酸(UDCA)对妊娠期肝内胆汁淤积症(ICP)孕妇血清胆汁酸谱的影响。方法:采用高效液相色谱串联质谱(HPLC-MS/MS)法检测ICP患者(孕期26-32周)接受UDCA治疗前及治疗后4周血清中7种胆汁酸的变化。结果:UDCA治疗ICP患者后与治疗前比较,血清肝功能指标丙氨酸氨基转移酶(ALT)、天门冬酸氨基转移酶(AST)、总胆红素(TBIL)、直接胆红素(DBIL)显著下降(P<0.05);ICP患者治疗前血清胆汁酸谱中,胆酸(CA)、甘氨胆酸(GCA)、牛磺胆酸(TCA)、牛磺石胆酸(TLCA)和石胆酸(LCA)水平均显著高于正常对照组(P<0.05);ICP患者治疗后与治疗前血清胆汁酸谱比较,UDCA显著升高,CA、GCA、TLCA和TCA显著下降,差异均具有统计学意义(P<0.05或P<0.01)。结论:UDCA能显著地降低ICP患者的高胆汁酸水平,其中CA、GCA、TCA、TLCA水平下降最为明显。
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| 关 键 词： | 妊娠期肝内胆汁淤积症 熊去氧胆酸 高效液相色谱串联质谱 胆汁酸谱 |
Serum Bile Acid Chromatograms of Pregnant Women with Intrahepatic Cholestasis Treated by Ursodeoxycholic Acid |
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| LING Ling LIU Zhao-ming,SHAO Yong,WANG Fu-lan. Serum Bile Acid Chromatograms of Pregnant Women with Intrahepatic Cholestasis Treated by Ursodeoxycholic Acid[J]. China Pharmacy, 2011, 0(26): 2438-2440 |
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| Authors: | LING Ling LIU Zhao-ming SHAO Yong WANG Fu-lan |
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| Affiliation: | LING Ling(Chongqing Red Cross Hospital,Chongqing 400020,China) LIU Zhao-ming,SHAO Yong,WANG Fu-lan(The First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China) |
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| Abstract: | OBJECTIVE:To investigate the changes of serum bile acid chromatograms before and after ursodeoxycholic acid (UDCA) in the treatment of intrahepatic cholestasis of pregnancy (ICP). METHODS: Seven types of serum bile acids were detected by HPLC-MS/MS in the ICP before and 4 weeks after UDCA treatment. RESULTS: After UDCA treatment, serum ALT, AST, TBIL and DBIL levels of the patients with ICP were significantly decreased (P<0.05). The serum levels of cholic acid (CA), glycocholic acid (GCA), taurocholic acid ... |
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| Keywords: | Intrahepatic cholestasis of pregnancy Ursodeoxycholic acid HPLC-MS/MS Bile acids chromatograms |
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