Protein kinase C modulation of the ethanol effect on serotonin2 receptor transduction in astrocytes |
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| Authors: | P Simonsson E Hansson C Alling |
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| Affiliation: | Department of Psychiatry and Neurochemistry, Lund University, Sweden. |
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| Abstract: | Acute ethanol exposure stimulated serotonin2 receptor signalling in cultured astrocytes. Pretreatment with the protein kinase C inhibitor H7 significantly increased the ethanol-induced potentiation of [3H]-inositol phosphates accumulation. The increase could be explained by an augmented activation of phospholipase C. The results indicate a role of PKC for the modulation of ethanol effects on cellular signalling. |
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