Association between donor-recipient serum sodium differences and orthotopic liver transplant graft function. |
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| Authors: | Jacek B Cywinski Edward Mascha Charles Miller Bijan Eghtesad Shunichi Nakagawa Joseph P Vincent Nick Pesa Jie Na John J Fung Brian M Parker |
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| Affiliation: | Department of General Anesthesiology, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland Clinic, Cleveland, OH 44195, USA. cywinsj@ccf.org |
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| Abstract: | ![]()
Previous studies have shown that donor hypernatremia and possibly recipient hyponatremia negatively impact graft function after orthotopic liver transplant (OLT). The purpose of this retrospective investigation was to determine whether measured differences in serum sodium values between cadaveric donors and OLT recipients (DeltaNa(+)) influence immediate postoperative allograft function and short-term patient outcomes. Two hundred and fifty patients that underwent OLT from January 2001 to December 2005 were included in this study. The DeltaNa(+) for each donor recipient pair was correlated with standard postoperative liver function tests as well as recipient length of intensive care unit stay (LOICUS), length of hospital stay (LOHS) and recipient survival. The relationship between donor hypernatremia (serum sodium >or= 155 mEq/mL), recipient hyponatremia (serum sodium level
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