围生因素与新生儿肺透明膜病发病关系的探讨

目的探讨围生因素与新生儿肺透明膜病(HMD)发病的关系。方法对481例早产儿围生因素进行Logistic回归分析,筛选出与HMD有关的因素,列出回归方程,然后对其进行率的比较及卡方检验。结果HMD危险因素的主效应模型是logit(p)=6.254-0.204胎龄-1.556出生体重 0.834窒息/宫内窘迫 1.635胎膜早破。对于有围生期合并症的早产儿,其胎龄越小,HMD发病率越高。结论30周以下早产儿HMD发病主要与胎龄、出生体重关系密切,而30周以上早产儿HMD发病除与胎龄、出生体重有关外,还与围生因素密切相关,其发病机制有待进一步研究。

Perinatal factors and hyaline membrane disease in preterm infant

Objective To investigate the correlation between perinatal factors and hyaline membrane disease(HMD) in preterm.Methods The perinatal factors of 481cases preterm infants were analyzed with Logistic regression analysis.We chose the risk factors that related to HMD and wrote Logistic regression equation.We compared morbidity of HMD with or without perinatal factors.Results The main effective model of high-risk factors in HMD was logit(p)=6.254-0.204GA(gestational age)-1.556WT(weight) 0.834A(asphyxia) 1.635 PROM(premature rupture of membranes).In the preterm infants,the smaller the gestational age was,the higher morbidity of HMD with perinatal factors was.Conclusion In preterm infant below 30 weeks,the main etiology of HMD is correlated with GA and WT.To premature infant above 30 weeks,its cause is not only correlated with GA and WT,but also correlated with perinatal factors closely.