| 肠溶阿斯匹林剂量和血阿斯匹林及水杨酸盐浓度与药效关系探讨 |
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| 引用本文： | 李义召,李大年,郭洪志,李明欣,周盛年,毕建忠,支洪波,郑金良. 肠溶阿斯匹林剂量和血阿斯匹林及水杨酸盐浓度与药效关系探讨[J]. 卒中与神经疾病, 1994, 0(4) |
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| 作者姓名： | 李义召 李大年 郭洪志 李明欣 周盛年 毕建忠 支洪波 郑金良 |
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| 作者单位： | 山东医科大学附属医院 |
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| 摘 要： | 本文探讨了ＡＳＡ剂量与药效的关系及血ＡＳＡ、ＳＡ药物浓度监测的临床意义，结果表明：（１）ＡＳＡ剂量与６－ｋｅｔｏ－ＰＧＦ_（１α）抑制率呈正相关（Ｐ＜０．０１），而与ＴＸＢ_２及ＰＡｇＲ抑制率无相关性（Ｐ＞０．１）；（２）本文采用ＨＰＬＣ内标法同时测定血ＡＳＡ和ＳＡ浓度，结果准确，方法简便；（３）当口服小剂量ＡＳＡ防治ＣＩ时，监测血ＡＳＡ和ＳＡ以调整ＡＳＡ用药剂量的临床价值并非十分重要。
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| 关 键 词： | 阿斯匹林，血药物浓度，血栓烷素B_2，6－酮－前列腺素F_（1α），血小板聚集率 |
Studies on the Relationships Between Dose of Enteric-Coated Aspirin and Concentration of Serum Acetylsalicylate and Salicylate or the Effect of drug |
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| Li Ylzhao, Li Danian, Guo Hongzhi,et al. Studies on the Relationships Between Dose of Enteric-Coated Aspirin and Concentration of Serum Acetylsalicylate and Salicylate or the Effect of drug[J]. Stroke and Nervous Diseases, 1994, 0(4) |
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| Authors: | Li Ylzhao Li Danian Guo Hongzhi et al |
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| Abstract: | The relationship between dose of enteric-coated aspirin and the effect was studied,and the clinical significance of measuring serum acetylsali -cylate (ASA)and salicylate(SA) was investigated, The present study showed that: (1)There was a positive correlation between dose of ASA and inhibition rate of 6-keto-PGF_(1a) (P<0.01),but not of TXB_2 and platelet aggregation rate (P> 0.1);(2)levels of the serum ASA and SA were measured by HPLC, it was a fast, sensitive and reliable method for measuring serum ASA and SA simultineously; (3)when low-dose ASA was administrated in the secondary prevention of stroke, the clinical significance of measuring serum ASA and SA was not important. |
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| Keywords: | Aspirin Blood drug concentratinon Thromboxane B_2 6-Keto-PGF_(1a) Platelet aggregation rate |
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