| 五龙颗粒对变态反应性鼻炎大鼠鼻黏膜组织白细胞介素mRNA表达的影响 |
| |
| 引用本文： | 付文洋,谢慧,熊大经. 五龙颗粒对变态反应性鼻炎大鼠鼻黏膜组织白细胞介素mRNA表达的影响[J]. 中国中医药信息杂志, 2007, 14(3): 28-30 |
| |
| 作者姓名： | 付文洋 谢慧 熊大经 |
| |
| 作者单位： | 1. 深圳市中医院,广东,深圳518000
2. 成都中医药大学,四川,成都610075 |
| |
| 摘 要： | 目的通过五龙颗粒对脾虚型变态反应性鼻炎(AR)大鼠白细胞介素-2、4、6 mRNA表达影响的研究,为健脾益气固表的五龙颗粒治疗AR提供理论依据。方法采用病证结合的方法造模,用RT-PCR法检测鼻黏膜白细胞介素mRNA的表达。结果五龙颗粒对实验性AR大鼠鼻黏膜处白细胞介素-2、4、6 mRNA的表达具有调节作用,升高的白细胞介素-4、6下降,降低的白细胞介素-2恢复。结论五龙颗粒可能通过调节细胞因子白细胞介素-2、4、6 mRNA的表达,对实验性AR大鼠发挥治疗作用。
|
| 关 键 词： | 五龙颗粒 变应性鼻炎 白细胞介素-2 mRNA 白细胞介素-4 mRNA 白细胞介素-6 mRNA |
| 文章编号： | 1005-5304（2007）03-0028-03 |
| 收稿时间： | 2006-07-20 |
| 修稿时间： | 2006-07-20 |
Effects of Wulong Granules on the Interlerkin mRNA Expression of Nasal Mucosa in Alergic Rhinitis Rats |
| |
| FU Wen-yang,XIE Hui,XIONG Da-jing. Effects of Wulong Granules on the Interlerkin mRNA Expression of Nasal Mucosa in Alergic Rhinitis Rats[J]. Chinese Journal of Information on Traditional Chinese Medicine, 2007, 14(3): 28-30 |
| |
| Authors: | FU Wen-yang XIE Hui XIONG Da-jing |
| |
| Affiliation: | 1.Shenzhen Hospital of TCM, Shenzhen 518000, China2.Chendu University ofTCM, Chengdu 610075, China |
| |
| Abstract: | Objective To study the effect of Wulong granules on the expression of IL-2 mRNA,IL-4 mRNA and IL-6 mRNA in allergic rhinitis(AR) rats in Spleen Qi deficiency type. To establish the clinic treatment principle-tonify Spleen and reinforce Qi of AR through the lab study. Methods Established AR model with combination of disease and Zheng,checked the expression of IL-2 mRNA,IL-4 mRNA and IL-6 mRNA of nasal mucosa were detected with RT-PCR. Results Wulong granules can adjust the expression of mRNA of AR rats' nasal mucosa. It can descend the ascensus of IL-4 mRNA,IL-6 mRNA and the drop of IL-2 mRNA. Conclusion Wulonggranules can show treatment effect to AR rats through adjusting the expression of cell factors such as IL-2 mRNA,IL-4 mRNA and IL-6 mRNA. |
| |
| Keywords: | Wulong-granules allergic rhinitis IL-2 mRNA IL-4 mRNA IL-6 mRNA |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
