| 芎芪合剂对缺血再灌注大鼠脑组织CD36及抗氧化相关指标的影响 |
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| 引用本文： | 付于,夏天,黄燕,黄培新.芎芪合剂对缺血再灌注大鼠脑组织CD36及抗氧化相关指标的影响[J].辽宁中医杂志,2009(9):1603-1606. |
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| 作者姓名： | 付于 夏天 黄燕 黄培新 |
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| 作者单位： | 天津中医药大学第一附属医院;广东省中医院; |
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| 基金项目： | 中国博士后基金项目(20060390722);;广东省科技计划项目(2006B35603007) |
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| 摘 要： | 目的:从氧化损伤角度,探讨芎芪合剂抗溶栓后脑缺血再灌注损伤的作用机理。方法:建立SD大鼠大脑中动脉闭塞(MCAO)及溶栓模型,模拟溶栓成功后的再灌注。运用病理TTC染色、组织生化检测和Northern b lot杂交的方法,进行脑梗死面积测定、抗氧化损伤相关指标(清道夫受体CD36基因表达、SOD、MDA、GSH-PX、NOS、iNOS含量)测定。结果:(1)芎芪合剂能够使SD大鼠缺血再灌注侧脑组织梗死面积明显缩小。(2)芎芪合剂能抑制缺血再灌注引起的清道夫受体CD36 mRNA表达增高;芎芪合剂能够调节缺血再灌注后SOD、MDA、GSH-PX、NOS、iNOS的含量,并使之趋向于正常。结论:(1)芎芪合剂具有抗脑缺血再灌注损伤的作用;(2)芎芪合剂能够通过减轻氧化应激损伤的程度达到抗脑缺血再灌注损伤的作用。
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| 关 键 词： | 芎芪合剂 脑缺血 再灌注损伤 CD36 氧化应激损伤 |
Effects on the CD36 and Anti-oxidant Targets of MCAO Rat After Cerebral Ischemical Reperfusion Injury by Xiong Qi Composition |
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| FU Yu,XIA Tian,HUANG Yan,HUANG Pei-xin,WANG Yong-yan.Effects on the CD36 and Anti-oxidant Targets of MCAO Rat After Cerebral Ischemical Reperfusion Injury by Xiong Qi Composition[J].Liaoning Journal of Traditional Chinese Medicine,2009(9):1603-1606. |
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| Authors: | FU Yu XIA Tian HUANG Yan HUANG Pei-xin WANG Yong-yan |
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| Institution: | 1.First Teaching Hospital of Tianjin Traditional Chinese Medicine College;Tianjin 300193;China;2.Tradi tional Chinese Medicine Hospital of Guangdong Provine;Guangzhou 510120;Guangdong;3.Tradi tional Chinese Medicine Colledge of Beijing;Beijing 100029;China |
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| Abstract: | Objective:From these aspects of anti-oxidant,we observe the integrated mechanism of Xiong Qi Composition resisting cerebral ischemical reperfusion injury after thrombolysis.Methods:MCAO model with nylon suture method of SD rat was set up.To simulate reperfusion after successful thrombolysis.With the organization biochemistry examination,TTC staining and Northern blot method,carrying on the detection of the infarct size,CD36 mRNA,SOD,MDA,GSH-PX,NOS,iNOS.Results:(1)Xiong Qi Composition can diminute the infarc... |
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| Keywords: | Xiong Qi Composition Cerebral ischemia Reperfusion injury CD36 Oxidative stress |
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